Literature summary for 3.4.22.56 extracted from

Roy, N.; Deveraux, Q.L.; Takahashi, R.; Salvesen, G.S.; Reed, J.C.
The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases (1997), EMBO J., 16, 6914-6925.

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Inhibitors

Inhibitors	Comment	Organism	Structure
cIAP2	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HEK-293 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
benzyloxycarbonyl-DEVD-7-amido-4-methylcoumarin + H2O	-	Homo sapiens	benzyloxycarbonyl-DEVD + 7-amino-4-methylcoumarin	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.000035	-	c-IAP-2	37°C	Homo sapiens
0.000108	-	c-IAP-1	37°C	Homo sapiens

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Release 2023.1 (January 2023)