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Literature summary for 3.4.22.56 extracted from

  • Thornberry, N.A.; Rano, T.A.; Peterson, E.P.; et al.
    A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis (1997), J. Biol. Chem., 272, 17907-17911.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification activation site is IETD (P4,P3,P2,P1) Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
70kDa U1 small ribonucleoprotein + H2O cleavage site is DGPD-/- Homo sapiens ?
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D4 G-protein dissociation inhibitor + H2O cleavage site is DELD-/- Homo sapiens ?
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DNA-dependent protein kinase CS + H2O cleavage site is DEVD-/- Homo sapiens ?
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huntingtin + H2O cleavage site is DEED-/- Homo sapiens ?
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additional information the preferred cleavage sequence is DEVD-/- Homo sapiens ?
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?
poly(ADP-ribose) polymerase + H2O cleavage site: DEVD-/- Homo sapiens ?
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?
sterol regulatory element-binding protein + H2O cleavage site is DEPD-/- Homo sapiens ?
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?