Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | caspase-2 is activated by proximity-induced oligomerization and trans-cleavage in vitro. Caspase-2 activation is possibly also mediated by caspase-8 in the death-inducing signaling complex | Mus musculus | |
PIDD protein | - |
Mus musculus | |
protein phosphatase 1 | - |
Mus musculus | |
RAIDD protein | - |
Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
cyclin-dependent kinase 1 | - |
Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
BID + H2O | Mus musculus | - |
? | - |
? | |
caspase-2 + H2O | Mus musculus | self-cleavage for activation | ? | - |
? | |
CERT + H2O | Mus musculus | - |
? | - |
? | |
DELTANp63 + H2O | Mus musculus | - |
? | - |
? | |
elF4B + H2O | Mus musculus | - |
? | - |
? | |
golgin-160 + H2O | Mus musculus | - |
? | - |
? | |
HDAC4 + H2O | Mus musculus | - |
? | - |
? | |
huntingtin + H2O | Mus musculus | - |
? | - |
? | |
ICAD + H2O | Mus musculus | - |
? | - |
? | |
MDM2 + H2O | Mus musculus | - |
? | - |
? | |
additional information | Mus musculus | caspase-2 is a substrate for caspase-8 and caspase-3 | ? | - |
? | |
pakin + H2O | Mus musculus | - |
? | - |
? | |
PARP + H2O | Mus musculus | - |
? | - |
? | |
protein kinase Cdelta + H2O | Mus musculus | - |
? | - |
? | |
ROCK1 + H2O | Mus musculus | - |
? | - |
? | |
ROCK2 + H2O | Mus musculus | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P29594 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | phosphorylation at Ser-340 | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
BID + H2O | - |
Mus musculus | ? | - |
? | |
caspase-2 + H2O | self-cleavage for activation | Mus musculus | ? | - |
? | |
CERT + H2O | - |
Mus musculus | ? | - |
? | |
DELTANp63 + H2O | - |
Mus musculus | ? | - |
? | |
elF4B + H2O | - |
Mus musculus | ? | - |
? | |
golgin-160 + H2O | - |
Mus musculus | ? | - |
? | |
HDAC4 + H2O | - |
Mus musculus | ? | - |
? | |
huntingtin + H2O | - |
Mus musculus | ? | - |
? | |
ICAD + H2O | - |
Mus musculus | ? | - |
? | |
MDM2 + H2O | - |
Mus musculus | ? | - |
? | |
additional information | caspase-2 is a substrate for caspase-8 and caspase-3 | Mus musculus | ? | - |
? | |
pakin + H2O | - |
Mus musculus | ? | - |
? | |
PARP + H2O | - |
Mus musculus | ? | - |
? | |
protein kinase Cdelta + H2O | - |
Mus musculus | ? | - |
? | |
ROCK1 + H2O | - |
Mus musculus | ? | - |
? | |
ROCK2 + H2O | - |
Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ICH-1 | formerly | Mus musculus |
NEDD-2 | formerly | Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | cells lacking caspase-2 are protected from cell death induced by Staphylococcus aureus alpha-toxin | Mus musculus |
physiological function | caspase-2 is implicated in the regulation of cell death that is induced by metabolic imbalance, DNA damage, endoplasmic reticulum (ER) stress, mitotic catastrophe and others. Caspase-2 is implicated in the induction of cell death by pathogenic bacteria, such as Brucella, Staphylococcus aureus and Salmonella. Caspase-2 is controlling aging and cell death in response to DNA damage. The enzyme is also linked to cell death that is induced by aberrant mitosis in cancer cells that transiently arrest in prometaphase after cell fusion. Caspase 2 is crucial for oocyte apoptosis | Mus musculus |