Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P29594 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bone marrow-derived macrophage | - |
Mus musculus | - |
RAW-264.7 cell | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
CASP-2 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | the loss of caspase-2 in mice results in an osteopenic phenotype associated with increased numbers of osteoclasts in vivo. Mitochondrial reactive oxygen species are significantly increased in caspase-deficient precursors after receptor activator of nuclear factor kappa-B ligand administration | Mus musculus |
physiological function | caspase-2 modulates osteoclastogenesis through down-regulating oxidative stress | Mus musculus |