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Literature summary for 3.4.22.55 extracted from

  • Guha, M.; Xia, F.; Raskett, C.M.; Altieri, D.C.
    Caspase 2-mediated tumor suppression involves survivin gene silencing (2010), Oncogene, 29, 1280-1292.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.55

Cloned(Commentary)

Cloned (Comment) Organism
GST-fusion contruct expressed in Escherichia coli BL21 Homo sapiens

Protein Variants

Protein Variants Comment Organism
C320A catalytic residue, inactive mutant enzyme Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Z-Val-Asp-Val-Ala-Asp-fluoromethylketone
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-Val-Asp-Val-Ala-Asp-4-nitroanilide + H2O
-
 Homo sapiens acetyl-Val-Asp-Val-Ala-Asp + 4-nitroaniline
-
 ?
NF kappaB activator + H2O RIP1 Homo sapiens ? proteolytic fragments of approximate 56 kDa and 20 kDa ?

Synonyms

Synonyms Comment Organism
caspase 2
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function caspase 2 represses transcription of the survivin gene, a general regulator of cell division and cytoprotection in tumors. This pathway involves caspase 2 proteolytic cleavage of the nuclearfactor kappaB (NFkappaB) activator, RIP1. Loss of RIP1 abolishes transcription of NFkappaB target genes, including survivin, resulting in deregulated mitotic transitions, enhanced apoptosis and suppression of tumorigenicityin vivo. Caspase 2 functions as an endogenous inhibitor of NFkappaB-dependent cell survival. Homo sapiens