Literature summary for 3.4.22.55 extracted from

Shi, M.; Vivian, C.J.; Lee, K.J.; Ge, C.; Morotomi-Yano, K.; Manzl, C.; Bock, F.; Sato, S.; Tomomori-Sato, C.; Zhu, R.; Haug, J.S.; Swanson, S.K.; Washburn, M.P.; Chen, D.J.; Chen, B.P.; Villunger, A.; Florens, L.; Du, C.
DNA-PKcs-PIDDosome: a nuclear caspase-2-activating complex with role in G2/M checkpoint maintenance (2009), Cell, 136, 508-520.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
nucleus	-	Mus musculus	5634	-
nucleus	-	Homo sapiens	5634	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Mus musculus	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
additional information	DNA damage induced by gamma-radiation triggers the phosphorylation of nuclear caspase-2 at S122 site within the prodomain leading to its cleavage and activation	Mus musculus
additional information	DNA damage induced by gamma-radiation triggers the phosphorylation of nuclear caspase-2 at S122 site within the prodomain leading to its cleavage and activation	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
embryonic fibroblast	-	Mus musculus	-
HEK-293 cell	-	Homo sapiens	-
HeLa cell	-	Homo sapiens	-
MEF cell	-	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
caspase-2	-	Mus musculus
caspase-2	-	Homo sapiens

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Release 2023.1 (January 2023)