Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.22.55 extracted from

  • Mohan, J.; Gandhi, A.A.; Bhavya, B.C.; Rashmi, R.; Karunagaran, D.; Indu, R.; Santhoshkumar, T.R.
    Caspase-2 triggers Bax-Bak-dependent and -independent cell death in colon cancer cells treated with resveratrol (2006), J. Biol. Chem., 281, 17599-17611.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast embryonic fibroblasts deficient for both Bax and Bak indicate the contribution of both Bax and Bak in mediating cell death induced by resveratrol and the existence of Bax/Bak-independent cell death possibly through caspase-8- or caspase-2-mediated mitochondria-independent downstream caspase processing Mus musculus
-
HCT-116 cell caspase-2 activation occurs upstream of mitochondria in resveratrol-treated cells. The activated caspase-2 triggers mitochondrial apoptotic events by inducing conformational changes in Bax/Bak with subsequent release of cytochrome c, apoptosis-inducing factor, and endonuclease G. Caspase-2 contributes toward the mitochondrial translocation of Bid Homo sapiens
-