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Literature summary for 3.4.22.55 extracted from

  • Tyagi, A.; Singh, R.P.; Agarwal, C.; Agarwal, R.
    Silibinin activates p53-caspase-2 pathway and causes caspase-mediated cleavage of Cip1/p21 in apoptosis induction in bladder transitional-cell papilloma RT4 cells: evidence for a regulatory loop between p53 and caspase-2 (2006), Carcinogenesis, 27, 2269-2280.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
silibinin caspase-2 and caspase-8 can activate each other in response to silibinin Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
pifithrin-alpha
-
 Homo sapiens
Z-Leu-Glu(OMe)-Thr-Asp(OMe)-CH2F
-
 Homo sapiens
Z-Val-Asp(OMe)-Val-Ala-Asp(OMe)-CH2F
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
13000
-
 1 * 13000 + 1 * ?, active form, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P42575
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bladder
-
 Homo sapiens
-
RT4 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
BID + H2O
-
 Homo sapiens ?
-
 ?
Cip1/p21 Bid + H2O
-
 Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
dimer 1 * 13000 + 1 * ?, active form, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
caspase-2
-
 Homo sapiens