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Literature summary for 3.4.22.54 extracted from
- Down-regulation of MyoD by calpain 3 promotes generation of reserve cells in C2C12 myoblasts (2010), J. Biol. Chem., 285, 12670-12683.
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | calpain 3 is a calcium-dependent cysteine protease | Mus musculus |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| C2C12 cell | - |
Mus musculus | - |
| myoblast | - |
Mus musculus | - |
| myotube | - |
Mus musculus | - |
| skeletal muscle | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| MyoD + H2O | calpain 3 down-regulates MyoD protein levels | Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| calpain 3 | - |
Mus musculus |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Mus musculus | reserve cells express higher levels of endogenous Capn3 mRNA than proliferating myoblasts | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | calpain 3 is involved in the myogenic differentiation process, calpain 3 participates in the establishment of the pool of reserve cells by decreasing the transcriptional activity of the key myogenic regulator MyoD via proteolysis independently of the ubiquitin-proteasome degradation pathway | Mus musculus |
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