BRENDA - Enzyme Database show
show all sequences of 3.4.22.54

Multiple molecular interactions implicate connectin/titin N2A region as a modulating scaffold for p94/calpain 3 activity in skeletal muscle

Hayashi, C.; Ono, Y.; Doi, N.; Kitamura, F.; Tagami, M.; Mineki, R.; Arai, T.; Taguchi, H.; Yanagida, M.; Hirner, S.; Labeit, D.; Labeit, S.; Sorimachi, H.; J. Biol. Chem. 23, 14801-14814 (2008)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
expression in COS-7 cells
Homo sapiens
expression in COS-7 cells
Mus musculus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
connectin + H2O
Homo sapiens
p94 binds to connectin at multiple sites including loci in the N2A and PEVK regions of connectin. Functionally, p94-N2A interactions suppress p94 autolysis and protected connectin from proteolysis. Dynamic nature of connectin molecule as a regulatory scaffold of p94 functions
?
-
-
?
connectin + H2O
Mus musculus
p94 binds to connectin at multiple sites including loci in the N2A and PEVK regions of connectin. Functionally, p94-N2A interactions suppress p94 autolysis and protected connectin from proteolysis. Dynamic nature of connectin molecule as a regulatory scaffold of p94 functions
?
-
-
?
MARP2/Ankrd2 + H2O
Homo sapiens
-
?
-
-
?
MARP2/Ankrd2 + H2O
Mus musculus
-
?
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
P20807
-
-
Mus musculus
Q64691
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
skeletal muscle
-
Homo sapiens
-
skeletal muscle
-
Mus musculus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
connectin + H2O
p94 binds to connectin at multiple sites including loci in the N2A and PEVK regions of connectin. Functionally, p94-N2A interactions suppress p94 autolysis and protected connectin from proteolysis. Dynamic nature of connectin molecule as a regulatory scaffold of p94 functions
680587
Homo sapiens
?
-
-
-
?
connectin + H2O
p94 binds to connectin at multiple sites including loci in the N2A and PEVK regions of connectin. Functionally, p94-N2A interactions suppress p94 autolysis and protected connectin from proteolysis. Dynamic nature of connectin molecule as a regulatory scaffold of p94 functions
680587
Mus musculus
?
-
-
-
?
MARP2/Ankrd2 + H2O
-
680587
Homo sapiens
?
-
-
-
?
MARP2/Ankrd2 + H2O
-
680587
Mus musculus
?
-
-
-
?
Cloned(Commentary) (protein specific)
Commentary
Organism
expression in COS-7 cells
Homo sapiens
expression in COS-7 cells
Mus musculus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
connectin + H2O
Homo sapiens
p94 binds to connectin at multiple sites including loci in the N2A and PEVK regions of connectin. Functionally, p94-N2A interactions suppress p94 autolysis and protected connectin from proteolysis. Dynamic nature of connectin molecule as a regulatory scaffold of p94 functions
?
-
-
?
connectin + H2O
Mus musculus
p94 binds to connectin at multiple sites including loci in the N2A and PEVK regions of connectin. Functionally, p94-N2A interactions suppress p94 autolysis and protected connectin from proteolysis. Dynamic nature of connectin molecule as a regulatory scaffold of p94 functions
?
-
-
?
MARP2/Ankrd2 + H2O
Homo sapiens
-
?
-
-
?
MARP2/Ankrd2 + H2O
Mus musculus
-
?
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
skeletal muscle
-
Homo sapiens
-
skeletal muscle
-
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
connectin + H2O
p94 binds to connectin at multiple sites including loci in the N2A and PEVK regions of connectin. Functionally, p94-N2A interactions suppress p94 autolysis and protected connectin from proteolysis. Dynamic nature of connectin molecule as a regulatory scaffold of p94 functions
680587
Homo sapiens
?
-
-
-
?
connectin + H2O
p94 binds to connectin at multiple sites including loci in the N2A and PEVK regions of connectin. Functionally, p94-N2A interactions suppress p94 autolysis and protected connectin from proteolysis. Dynamic nature of connectin molecule as a regulatory scaffold of p94 functions
680587
Mus musculus
?
-
-
-
?
MARP2/Ankrd2 + H2O
-
680587
Homo sapiens
?
-
-
-
?
MARP2/Ankrd2 + H2O
-
680587
Mus musculus
?
-
-
-
?
Other publictions for EC 3.4.22.54
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
731896
Charton
CAPN3-mediated processing of C ...
Homo sapiens, Mus musculus
Hum. Mol. Genet.
24
3718-3731
2015
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2
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4
4
-
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-
732188
Ermolova
Autolytic activation of calpai ...
Mus musculus
J. Biol. Chem.
290
996-1004
2015
1
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1
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1
1
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1
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1
1
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1
1
-
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732672
Pistoni
Rbfox1 downregulation and alte ...
Homo sapiens, Mus musculus
PLoS Genet.
9
e1003186
2013
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6
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3
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2
2
2
2
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709092
Stuelsatz
Down-regulation of MyoD by cal ...
Mus musculus
J. Biol. Chem.
285
12670-12683
2010
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1
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1
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1
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4
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1
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1
1
1
1
-
-
709121
Ono
Skeletal muscle-specific calpa ...
Rattus norvegicus
J. Biol. Chem.
285
22986-22998
2010
-
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2
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2
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5
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2
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1
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1
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5
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1
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5
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709883
Gornik
Molecular cloning and localiza ...
Nephrops norvegicus
Mol. Biol. Rep.
37
2009-2019
2010
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1
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4
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1
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1
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1
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1
1
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-
717589
Laure
A new pathway encompassing cal ...
Homo sapiens
FEBS J.
277
4322-4337
2010
-
-
1
-
1
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1
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2
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1
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1
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1
1
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718255
Roperto
Calpain3 is expressed in a pro ...
Bos taurus
PLoS ONE
5
e10299
2010
-
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-
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2
1
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1
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5
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2
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1
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1
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718257
de Morree
Calpain 3 is a rapid-action, u ...
Homo sapiens
PLoS ONE
5
e11940
2010
-
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1
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1
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1
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3
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-
696327
Garnham
Limb-girdle muscular dystrophy ...
Homo sapiens
Biochemistry
48
3457-3467
2009
-
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-
1
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3
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1
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1
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1
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696975
Zhang
Identification and association ...
Gallus gallus
BMC Genet.
10
10
2009
-
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1
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2
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698991
Murphy
Endogenous calpain-3 activatio ...
Rattus norvegicus
J. Biol. Chem.
284
7811-7819
2009
1
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1
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2
1
1
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1
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1
1
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2
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1
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707560
Mellgren
Calcium-dependent plasma membr ...
Mus musculus
Biochim. Biophys. Acta
1793
1886-1893
2009
-
-
-
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-
-
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1
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3
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1
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1
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1
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1
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1
-
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2
2
-
-
-
708013
Moretti
Novel variants of muscle calpa ...
Homo sapiens
Carcinogenesis
30
960-967
2009
-
-
-
-
-
-
-
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2
-
1
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2
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8
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2
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1
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8
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-
1
1
1
1
-
-
708490
Ravulapalli
Distinguishing between calpain ...
Homo sapiens
FEBS J.
276
973-982
2009
-
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1
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1
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1
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708654
Kramerova
Mitochondrial abnormalities, e ...
Mus musculus
Hum. Mol. Genet.
18
3194-3205
2009
-
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1
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1
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1
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2
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1
1
-
-
-
708776
Dayanithi
Alteration of sarcoplasmic ret ...
Mus musculus
Int. J. Cell Biol.
2009
340346
2009
-
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1
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1
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3
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1
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2
2
-
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-
708827
Mora
Naturally generated small pept ...
Sus scrofa
J. Agric. Food Chem.
57
3228-3234
2009
-
-
-
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1
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1
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710092
Charlton
Immunohistochemical analysis o ...
Homo sapiens
Neuromuscul. Disord.
19
449-457
2009
-
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1
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2
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1
1
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-
680082
Huang
Calpain 3 is a modulator of th ...
Homo sapiens
Hum. Mol. Genet.
17
1855-1866
2008
-
-
-
-
-
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1
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2
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1
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1
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2
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680587
Hayashi
Multiple molecular interaction ...
Homo sapiens, Mus musculus
J. Biol. Chem.
23
14801-14814
2008
-
-
2
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4
-
3
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2
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4
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4
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2
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4
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696977
Barendse
Variation at the Calpain 3 gen ...
Bos taurus
BMC Genet.
9
41
2008
-
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-
2
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4
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Effects of concentric and repe ...
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Kramerova
Novel role of calpain-3 in the ...
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700440
Blazquez
Characterization of novel CAPN ...
Homo sapiens
Neurogenetics
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700446
Beckmann
Calpain 3, the 'gatekeeper' of ...
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Screening of calpain-3 autolyt ...
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677414
Norton
Characterization of GLUT4 and ...
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2007
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677560
Yang
Muscle type-specific responses ...
Sus scrofa
Animal
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2007
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NF-{kappa}B-dependent expressi ...
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680264
Tang
Age-related cataracts in alpha ...
Mus musculus
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680421
Murphy
Calpain-3 is autolyzed and hen ...
Homo sapiens
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2007
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Ojima
Myogenic stage, sarcomere leng ...
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663588
Murphy
m-Calpain and calpain-3 are no ...
Homo sapiens, Rattus norvegicus
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C116-C122
2006
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664132
Garcia Diaz
Ca2+ dependency of calpain 3 ( ...
Homo sapiens
Biochemistry
45
3714-3722
2006
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664915
Duguez
Calpain 3: a key regulator of ...
Homo sapiens
FEBS J.
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3427-3436
2006
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670251
Kramerova
Regulation of the M-cadherin-b ...
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2006
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670856
Cohen
Identification of putative in ...
Mus musculus
Proteomics
6
6075-6084
2006
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Ravulapalli
Homodimerization of calpain 3 ...
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585-591
2005
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664470
Saenz
LGMD2A: genotype-phenotype cor ...
Homo sapiens
Brain
128
732-742
2005
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665131
Kramerova
Calpain 3 participates in sarc ...
Mus musculus
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2005
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665133
Huebsch
Mdm muscular dystrophy: intera ...
Mus musculus
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2801-2811
2005
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665314
Geesink
Calpain 3/p94 is not involved ...
Mus musculus
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83
1646-1652
2005
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665129
Kramerova
Null mutation of calpain 3 (p9 ...
Mus musculus
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665528
Ono
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279
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Diaz
Insertion sequence 1 of muscle ...
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279
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Boeckmann
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Bos taurus, Homo sapiens, Mus musculus, Sus scrofa
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de Tullio
Characterization of a new p94- ...
Homo sapiens
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Guyon
Calpain 3 cleaves filamin C an ...
Mus musculus, Rattus norvegicus
Muscle Nerve
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The protease core of the muscl ...
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1
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1
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649033
Welm
C/EBPalpha is required for pro ...
Homo sapiens, Mus musculus
J. Biol. Chem.
277
33848-33856
2002
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2
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5
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4
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2
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4
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-
643974
Nakajima
Different expression patterns ...
Macaca fascicularis
Biochim. Biophys. Acta
1519
55-64
2001
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1
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6
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2
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2
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644004
Ilian
Intermuscular variation in ten ...
Bos taurus, Ovis aries
J. Anim. Sci.
79
122-132
2001
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3
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6
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6
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649030
Jia
Mutations in calpain 3 associa ...
Homo sapiens
Biophys. J.
80
2590-2596
2001
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1
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1
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2
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1
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1
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1
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1
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-
649018
Richard
Calpainopathy - a survey of mu ...
Homo sapiens
Am. J. Hum. Genet.
64
1524-1540
1999
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1
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2
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1
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1
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1
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1
-
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1
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649026
Nonneman
Molecular cloning and mapping ...
Bos taurus, Ovis aries
Anim. Genet.
30
456-458
1999
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2
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2
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1
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1
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649022
Urtasun
-
Limb-girdle muscular dystrophy ...
Homo sapiens
Brain
121
1735-1747
1998
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1
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1
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1
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1
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1
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1
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1
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1
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1
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649023
Haeffner
-
A small in-frame deletion with ...
Homo sapiens
Hum. Mutat.
1
S298-S300
1998
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1
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1
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1
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1
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1
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1
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1
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1
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1
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-
649024
Penisson-Besnier
Pseudometabolic expression and ...
Homo sapiens
Muscle Nerve
21
1078-1080
1998
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1
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1
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1
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1
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1
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1
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1
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1
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1
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649025
Kawai
Clinical, pathological, and ge ...
Homo sapiens
Muscle Nerve
21
1493-1501
1998
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1
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2
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2
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1
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2
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649015
Richard
Multiple independent molecular ...
Homo sapiens, Sus scrofa
Am. J. Hum. Genet.
60
1128-1138
1997
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1
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3
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1
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1
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2
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1
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649021
Dincer
A biochemical, genetic, and cl ...
Homo sapiens
Ann. Neurol.
42
222-229
1997
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1
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3
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1
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1
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1
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1
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1
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649014
Briley G.P.; Riggs P.K.; Womack
Chromosomal localization of th ...
Sus scrofa
Mamm. Genome
7
226-228
1996
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1
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3
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649019
Fardeau
-
Juvenile limb-girdle muscular ...
Homo sapiens
Brain
119
295-308
1996
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1
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1
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1
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1
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1
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1
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649035
Richard
Molecular cloning of mouse can ...
Mus musculus
Mamm. Genome
7
377-379
1996
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1
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1
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1
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1
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1
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1
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1
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644015
Sorimachi H.; Tsukahara T.; Okada-Ban M.; Sugita H.; Ishiura S.; Suzuki K.
Identification of a third ubiq ...
Gallus gallus
Biochim. Biophys. Acta
1261
381-393
1995
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1
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1
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649020
Richard
Mutations in the proteolytic e ...
Homo sapiens
Cell
81
27-40
1995
-
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1
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2
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1
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1
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1
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1
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1
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-
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649032
Sorimachi
New era of calpain research. D ...
Gallus gallus, Homo sapiens, Rattus norvegicus
FEBS Lett.
343
1-5
1994
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3
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3
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3
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649012
Sorimachi H.; Imajoh-Ohmi S.; Emori Y.; Kawasaki H.; Ohno S.; Minami Y.; Suzuki K.
Molecular cloning of a novel m ...
Homo sapiens, Rattus norvegicus
J. Biol. Chem.
264
20106-20111
1989
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1
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2
1
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2
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2
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1
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1
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1
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2
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1
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