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Literature summary for 3.4.22.54 extracted from

  • Jia, Z.; Petrounevitch, V.; Wong, A.; Moldoveanu, T.; Davies, P.L.; Elce, J.S.; Beckmann, J.S.
    Mutations in calpain 3 associated with limb girdle muscular dystrophy: analysis by molecular modeling and by mutation in m-calpain (2001), Biophys. J., 80, 2590-2596.
    View publication on PubMedView publication on EuropePMC
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General Stability

General Stability Organism
rapid autodigestion Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens limb-girdle muscular dystrophy type 2A is an autosomal recessive disorder characterized by selective atrophy of the proximal limb muscles. Its occurence is correlated, in a large number of patients, with defects ihn the human CAP3 gene. The most calpain 3 missense mutations are clustered in three areas that appear to affect intramolecular domain interactions and may impair the assembly and activation of this multi-domain protein ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information limb-girdle muscular dystrophy type 2A is an autosomal recessive disorder characterized by selective atrophy of the proximal limb muscles. Its occurence is correlated, in a large number of patients, with defects ihn the human CAP3 gene. The most calpain 3 missense mutations are clustered in three areas that appear to affect intramolecular domain interactions and may impair the assembly and activation of this multi-domain protein Homo sapiens ?
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