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Literature summary for 3.4.22.54 extracted from

  • de Tullio, R.; Stifanese, R.; Salamino, F.; Pontremoli, S.; Melloni, E.
    Characterization of a new p94-like calpain form in human lymphocytes (2003), Biochem. J., 375, 689-696.
    View publication on PubMedView publication on EuropePMC

General Stability

General Stability Organism
autodigestion with 50% loss of total activity after exposure to 0.1 mM Ca2+ Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
calpain inhibitor I IC50: 0.00025 mM Homo sapiens
calpain inhibitor II IC50: 0.00025 mM Homo sapiens
leupeptin IC50: 0.002 mM Homo sapiens
recombinant rat brain calpastatin IC50: 0.0036 mM Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ required, K0.5 is between 0.02 and 0.03 mM Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the selective distribution of the enzyme in T-lymphocytes, B-lymphocytes and natural killer cells , might be related to a specific function of this protease isoform in cells involved in the immune response ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
B-lymphocyte
-
Homo sapiens
-
additional information activity is almost undetectable in polymorphonuclear cells Homo sapiens
-
natural killer cell poor expression Homo sapiens
-
T-lymphocyte
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the selective distribution of the enzyme in T-lymphocytes, B-lymphocytes and natural killer cells , might be related to a specific function of this protease isoform in cells involved in the immune response Homo sapiens ?
-
?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00025
-
IC50: 0.00025 mM Homo sapiens calpain inhibitor I
0.00025
-
IC50: 0.00025 mM Homo sapiens calpain inhibitor II
0.002
-
IC50: 0.002 mM Homo sapiens leupeptin
0.0036
-
IC50: 0.0036 mM Homo sapiens recombinant rat brain calpastatin