General Stability | Organism |
---|---|
autodigestion with 50% loss of total activity after exposure to 0.1 mM Ca2+ | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
calpain inhibitor I | IC50: 0.00025 mM | Homo sapiens | |
calpain inhibitor II | IC50: 0.00025 mM | Homo sapiens | |
leupeptin | IC50: 0.002 mM | Homo sapiens | |
recombinant rat brain calpastatin | IC50: 0.0036 mM | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | required, K0.5 is between 0.02 and 0.03 mM | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the selective distribution of the enzyme in T-lymphocytes, B-lymphocytes and natural killer cells , might be related to a specific function of this protease isoform in cells involved in the immune response | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
B-lymphocyte | - |
Homo sapiens | - |
additional information | activity is almost undetectable in polymorphonuclear cells | Homo sapiens | - |
natural killer cell | poor expression | Homo sapiens | - |
T-lymphocyte | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the selective distribution of the enzyme in T-lymphocytes, B-lymphocytes and natural killer cells , might be related to a specific function of this protease isoform in cells involved in the immune response | Homo sapiens | ? | - |
? |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00025 | - |
IC50: 0.00025 mM | Homo sapiens | calpain inhibitor I | |
0.00025 | - |
IC50: 0.00025 mM | Homo sapiens | calpain inhibitor II | |
0.002 | - |
IC50: 0.002 mM | Homo sapiens | leupeptin | |
0.0036 | - |
IC50: 0.0036 mM | Homo sapiens | recombinant rat brain calpastatin |