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Literature summary for 3.4.22.53 extracted from

  • Huang, C.; Gurlo, T.; Haataja, L.; Costes, S.; Daval, M.; Ryazantsev, S.; Wu, X.; Butler, A.; Butler, P.
    Calcium-activated calpain-2 is a mediator of beta cell dysfunction and apoptosis in type 2 diabetes (2010), J. Biol. Chem., 285, 339-348.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
benzyloxycarbonyl-LLY-fluoromethylketone
-
Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ activates Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
58000
-
x * 58000, active form, SDS-PAGE Rattus norvegicus
80000
-
x * 80000, inactive form, SDS-PAGE Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
INS-1 832/13 cell
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-acetyl-LLY-7-amido-4-trifluoromethylcoumarin + H2O
-
Rattus norvegicus N-acetyl-LLY + 7-amino-4-trifluoromethylcoumarin
-
?

Subunits

Subunits Comment Organism
? x * 58000, active form, SDS-PAGE Rattus norvegicus
? x * 80000, inactive form, SDS-PAGE Rattus norvegicus

Synonyms

Synonyms Comment Organism
m-calpain
-
Rattus norvegicus

General Information

General Information Comment Organism
physiological function calpain-2 is a mediator of beta cell dysfunction and apoptosis in type 2 diabetes Rattus norvegicus