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Literature summary for 3.4.22.53 extracted from

  • Silver, K.; Leloup, L.; Freeman, L.C.; Wells, A.; Lillich, J.D.
    Non-steroidal anti-inflammatory drugs inhibit calpain activity and membrane localization of calpain 2 protease (2010), Int. J. Biochem. Cell Biol., 42, 2030-2036.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.53

Inhibitors

Inhibitors Comment Organism Structure
ALLM
-
 Mus musculus
indomethacin
-
 Mus musculus
NS-398
-
 Mus musculus
SC-560
-
 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Mus musculus 16020
-
plasma membrane
-
 Mus musculus 5886
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
80000
-
 x * 80000, SDS-PAGE Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
IEC-6 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
tert-butoxycarbonyl-Leu-Met-7-amido-4-chloromethylcoumarin + H2O
-
 Mus musculus tert-butoxycarbonyl-Leu-Met + 7-amino-4-chloromethylcoumarin
-
 ?

Subunits

Subunits Comment Organism
? x * 80000, SDS-PAGE Mus musculus

Synonyms

Synonyms Comment Organism
calpain 2
-
 Mus musculus

Expression

Organism Comment Expression
Homo sapiens 0.1 mM indomethacin and 0.1 mM NS-398 decrease expression of calpain 2 in total membrane fractions and in plasma membranes by 70%, while 0.001 mM SC-560 decreases expression of calpain 2 in total membrane fractions and in plasma membranes by 30% down

General Information

General Information Comment Organism
malfunction inhibition of calpain activity limits cell migration and in vitro wound healing of IEC-6 cells Homo sapiens