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Literature summary for 3.4.22.53 extracted from

  • Liu, W.; Zhou, X.W.; Liu, S.; Hu, K.; Wang, C.; He, Q.; Li, M.
    Calpain-truncated CRMP-3 and -4 contribute to potassium deprivation-induced apoptosis of cerebellar granule neurons (2009), Proteomics, 9, 3712-3728.
    View publication on PubMed
Search for more literature for 3.4.22.53

Inhibitors

Inhibitors Comment Organism Structure
acetyl-Leu-Leu-Met-CHO selectively inhibits the activity of calpain-2 Rattus norvegicus
acetyl-Leu-Leu-Nle-CHO
-
 Rattus norvegicus
additional information not inhibited by benzyloxycarbonyl-VAD-fluoromethylketone Rattus norvegicus
PD150606
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
alpha-spectrin + H2O Rattus norvegicus
-
 145000 Da fragment + ?
-
 ?
aminopeptidase B + H2O Rattus norvegicus
-
 ?
-
 ?
beta-transducin repeat containing protein + H2O Rattus norvegicus
-
 ?
-
 ?
caspase-3 + H2O Rattus norvegicus
-
 ?
-
 ?
collapsin response mediator protein-1 + H2O Rattus norvegicus collapsin response mediator protein-1 is cleaved by calpain-2 at the C-terminus ?
-
 ?
collapsin response mediator protein-2 + H2O Rattus norvegicus collapsin response mediator protein-2 is cleaved by calpain-2 at the C-terminus ?
-
 ?
collapsin response mediator protein-4 + H2O Rattus norvegicus collapsin response mediator protein-4 is cleaved by calpain-2 at the C-terminus ?
-
 ?
collapsin response mediator protein-5 + H2O Rattus norvegicus
-
 ?
-
 ?
frequenin homolog + H2O Rattus norvegicus
-
 ?
-
 ?
heterogeneous nuclear ribonucleoprotein F + H2O Rattus norvegicus
-
 ?
-
 ?
heterogeneous nuclear ribonucleoprotein K + H2O Rattus norvegicus
-
 ?
-
 ?
internexin + H2O Rattus norvegicus
-
 ?
-
 ?
laminin receptor 1 + H2O Rattus norvegicus
-
 ?
-
 ?
microtubule-associated protein 1B + H2O Rattus norvegicus
-
 ?
-
 ?
neurofilament + H2O Rattus norvegicus
-
 ?
-
 ?
nucleolin + H2O Rattus norvegicus
-
 ?
-
 ?
p35 + H2O Rattus norvegicus calpain-specific substrate 25000 Da fragment of p35 + ?
-
 ?
synaptotagmin-1 + H2O Rattus norvegicus
-
 ?
-
 ?
transgelin-3 + H2O Rattus norvegicus
-
 ?
-
 ?
ubiquitin-activating enzyme E1 + H2O Rattus norvegicus
-
 ?
-
 ?
vimentin + H2O Rattus norvegicus
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cerebellar granule cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha-spectrin + H2O
-
 Rattus norvegicus 145000 Da fragment + ?
-
 ?
aminopeptidase B + H2O
-
 Rattus norvegicus ?
-
 ?
beta-transducin repeat containing protein + H2O
-
 Rattus norvegicus ?
-
 ?
caspase-3 + H2O
-
 Rattus norvegicus ?
-
 ?
collapsin response mediator protein-1 + H2O collapsin response mediator protein-1 is cleaved by calpain-2 at the C-terminus Rattus norvegicus ?
-
 ?
collapsin response mediator protein-2 + H2O collapsin response mediator protein-2 is cleaved by calpain-2 at the C-terminus Rattus norvegicus ?
-
 ?
collapsin response mediator protein-4 + H2O collapsin response mediator protein-4 is cleaved by calpain-2 at the C-terminus Rattus norvegicus ?
-
 ?
collapsin response mediator protein-5 + H2O
-
 Rattus norvegicus ?
-
 ?
frequenin homolog + H2O
-
 Rattus norvegicus ?
-
 ?
heterogeneous nuclear ribonucleoprotein F + H2O
-
 Rattus norvegicus ?
-
 ?
heterogeneous nuclear ribonucleoprotein K + H2O
-
 Rattus norvegicus ?
-
 ?
internexin + H2O
-
 Rattus norvegicus ?
-
 ?
laminin receptor 1 + H2O
-
 Rattus norvegicus ?
-
 ?
microtubule-associated protein 1B + H2O
-
 Rattus norvegicus ?
-
 ?
neurofilament + H2O
-
 Rattus norvegicus ?
-
 ?
nucleolin + H2O
-
 Rattus norvegicus ?
-
 ?
p35 + H2O calpain-specific substrate Rattus norvegicus 25000 Da fragment of p35 + ?
-
 ?
synaptotagmin-1 + H2O
-
 Rattus norvegicus ?
-
 ?
transgelin-3 + H2O
-
 Rattus norvegicus ?
-
 ?
ubiquitin-activating enzyme E1 + H2O
-
 Rattus norvegicus ?
-
 ?
vimentin + H2O
-
 Rattus norvegicus ?
-
 ?