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Literature summary for 3.4.22.53 extracted from

  • Lizama, C.; Lagos, C.F.; Lagos-Cabre, R.; Cantuarias, L.; Rivera, F.; Huenchunir, P.; Perez-Acle, T.; Carrion, F.; Moreno, R.D.
    Calpain inhibitors prevent p38 MAPK activation and germ cell apoptosis after heat stress in pubertal rat testes (2009), J. Cell. Physiol., 221, 296-305.
    View publication on PubMed
Search for more literature for 3.4.22.53

Inhibitors

Inhibitors Comment Organism Structure
(2S)-3-phenyl-2-([[(2S)-1-(phenylsulfonyl)pyrrolidin-2-yl]carbonyl]amino)propanoic acid
-
 Rattus norvegicus
(2S)-4-methyl-2-[(phenylsulfonyl)amino]pentanoic acid
-
 Rattus norvegicus
ethyl N-(phenylsulfonyl)-L-leucyl-L-phenylalaninate
-
 Rattus norvegicus
MDL28170 selective calpain inhibitor Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
testis
-
 Rattus norvegicus
-

Synonyms

Synonyms Comment Organism
calpain 2
-
 Rattus norvegicus
CAPN2
-
 Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00014
-
 temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4 Rattus norvegicus (2S)-3-phenyl-2-([[(2S)-1-(phenylsulfonyl)pyrrolidin-2-yl]carbonyl]amino)propanoic acid
0.00015
-
 temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4 Rattus norvegicus MDL28170
0.00024
-
 temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4 Rattus norvegicus ethyl N-(phenylsulfonyl)-L-leucyl-L-phenylalaninate
0.00041
-
 temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4 Rattus norvegicus (2S)-4-methyl-2-[(phenylsulfonyl)amino]pentanoic acid

Expression

Organism Comment Expression
Rattus norvegicus a heat stress stimulus induces massive germ cells apoptosis, which is associated with an increase in the levels of mRNA encoding calpain 2 up

General Information

General Information Comment Organism
malfunction the blockage of calpain 2 suppresses p38 MAPK phosphorylation Rattus norvegicus
physiological function calpain 2 activation is an early event in heat stress-induced male germ cell apoptosis Rattus norvegicus