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Literature summary for 3.4.22.53 extracted from

  • Rudinskiy, N.; Grishchuk, Y.; Vaslin, A.; Puyal, J.; Delacourte, A.; Hirling, H.; Clarke, P.G.; Luthi-Carter, R.
    Calpain hydrolysis of alpha- and beta2-adaptins decreases clathrin-dependent endocytosis and may promote neurodegeneration (2009), J. Biol. Chem., 284, 12447-12458.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
acetyl-Leu-Leu-Nle-CHO broad spectrum calpain inhibitor Rattus norvegicus
benzyloxycarbonyl-LLY-fluoromethylketone
-
 Rattus norvegicus
EDTA completely inactivated by 4 mM EDTA plus 4 mM EGTA Rattus norvegicus
EGTA completely inactivated by 4 mM EDTA plus 4 mM EGTA Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ required for activity Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha-adaptin + H2O
-
 Rattus norvegicus ?
-
 ?
beta2-adaptin + H2O
-
 Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
calpain 2
-
 Rattus norvegicus