Inhibitors | Comment | Organism | Structure |
---|---|---|---|
N-acetyl-L-leucyl-L-leucyl-L-methioninal | - |
Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
aorta | relatively high m-calpain expression levels in the inferior arch | Mus musculus | - |
vascular endothelial cell | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
m-calpain | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | m-calpain expression levels in aorta in siRNAtreated mice are significantly diminished by 63.5% in comparison to those in control RNA-transfected mice with no alteration of m-calpain or beta-actin expression | down |
General Information | Comment | Organism |
---|---|---|
malfunction | short interfering RNA-induced silencing of m-calpain results in increased RhoA activity and hyperpermeability in the aortic arch, which is accompanied by ROCK inhibitor-sensitive phosphorylation of downstream effecter LIM kinase 2, stress fibre accumulation in endothelium and enhanced interendothelial gaps | Mus musculus |
physiological function | m-calpain antagonizes RhoA overactivation and endothelial barrier dysfunction under disturbed shear conditions | Mus musculus |