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Literature summary for 3.4.22.52 extracted from

  • Baudry, M.; Bi, X.
    calpain-1 and calpain-2 The Yin and Yang of synaptic plasticity and neurodegeneration (2016), Trends Neurosci., 39, 235-245 .
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Homo sapiens P07384 catalytic subunit
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Source Tissue

Source Tissue Comment Organism Textmining
brain
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Homo sapiens
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General Information

General Information Comment Organism
physiological function calpain-1 and calpain-2 play opposite functions in both synaptic plasticity/learning and memory and neuroprotection/neurodegeneration. Calpain-1 activation is necessary for certain forms of synaptic plasticity and learning and memory, while calpain-2 activation during a brief consolidation period limits the extent of plasticity/learning. Calpain-1 is neuroprotective, while calpain-2 is neurodegenerative Homo sapiens