Inhibitors | Comment | Organism | Structure |
---|---|---|---|
MDL-28170 | - |
Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | present mostly in the intermembrane space | Mus musculus | 5739 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | activation of mu-calpain requires micromolar calcium (0.4 mM used in assays) | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
apoptosis inducing factor + H2O | Mus musculus | - |
truncated apoptosis inducing factor + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
apoptosis inducing factor + H2O | - |
Mus musculus | truncated apoptosis inducing factor + ? | - |
? | |
succinyl-L-Leu-L-Tyr-7-amido-4-methylcoumarin + H2O | - |
Mus musculus | succinyl-L-Leu-L-Tyr + 7-amino-4-methylcoumarin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
calpain I | - |
Mus musculus |
mito-mu-calpain | - |
Mus musculus |
mu-calpain | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | mitochondrial mu-calpain activity is increased by 160% during ischemia-reperfusion compared to time control | up |
General Information | Comment | Organism |
---|---|---|
physiological function | exogenous calcium treatment induces a calpain-dependent decrease of mitochondrial apoptosis inducing factor content in isolated mouse heart mitochondria | Mus musculus |