Any feedback?
Literature summary for 3.4.22.52 extracted from
- Inhibition of calpain increases LIS1 expression and partially rescues in vivo phenotypes in a mouse model of lissencephaly (2009), Nat. Med., 15, 1202-1207.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | the inhibition of calpain is a potential therapeutic intervention for lissencephaly | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ALLN | - |
Mus musculus |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| MEF cell | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| LIS1 protein + H2O | - |
Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| calpain I | - |
Mus musculus |
| mu-calpain | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | in utero knockdown of calpain by shRNA rescues defective cortical layering in heterozygous Lis1+/? mice | Mus musculus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
