Inhibitors | Comment | Organism | Structure |
---|---|---|---|
calpeptin | - |
Homo sapiens | |
PD150606 | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | - |
Homo sapiens | - |
ASTC-a-1 cell | - |
Homo sapiens | - |
lung adenocarcinoma cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
apoptosis-inducing factor + H2O | micro-calpain mediates the truncation and release of apoptosis-inducing factor from mitochondria following cisplatin treatment | Homo sapiens | ? | - |
? | |
N-acetyl-LLY-7-amido-4-fluoromethylcoumarin + H2O | - |
Homo sapiens | N-acetyl-LLY + 7-amino-4-fluoromethylcoumarin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
micro-calpain | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | after cisplatin treatment, calpain activation is an early event | up |
General Information | Comment | Organism |
---|---|---|
malfunction | inhibition of micro-calpain not only significantly reduces caspase-9/-3 activities but also completely blocks apoptosis-inducing factor redistribution | Homo sapiens |
physiological function | activation of micro-calpain plays an essential role in regulating both caspase-dependent and apoptosis-inducing factor-mediated caspase-independent apoptotic pathways in cisplatin-induced apoptosis | Homo sapiens |