Inhibitors | Comment | Organism | Structure |
---|---|---|---|
calpastatin | mitochondrial mu-calpain is tightly regulated by its endogenous inhibitor calpastatin | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | neuronal cytosol | Rattus norvegicus | 5829 | - |
mitochondrion | mu-calpain, including both the large and small subunits is present in the mitochondrial intermembrane space | Rattus norvegicus | 5739 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | the enzyme is Ca2+-dependent | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
mature apoptosis-inducing factor (62 kDa) + H2O | Rattus norvegicus | cleaved by the mitochondrial mu-calpain near its N-terminus | cleaved apoptosis-inducing factor (57 kDa) + ? | - |
? | |
mitochondrial major Ca2+ extruding pathway Na+/Ca2+ exchanger + H2O | Rattus norvegicus | cleaved by the mitochondrial mu-calpain | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
neuron | - |
Rattus norvegicus | - |
smooth muscle | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
mature apoptosis-inducing factor (62 kDa) + H2O | cleaved by the mitochondrial mu-calpain near its N-terminus | Rattus norvegicus | cleaved apoptosis-inducing factor (57 kDa) + ? | - |
? | |
mitochondrial major Ca2+ extruding pathway Na+/Ca2+ exchanger + H2O | cleaved by the mitochondrial mu-calpain | Rattus norvegicus | ? | - |
? | |
additional information | mitochondrial mu-calpain associates with ERp57, whereas, cytosolic mu-calpain does not associate with ERp57 | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
calpain 1 | - |
Rattus norvegicus |
mu-calpain | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | mu-calpain is activated in neurons after ischemia | up |
General Information | Comment | Organism |
---|---|---|
physiological function | mitochondrial mu-calpain is an initiator of the apoptosis-inducing factor-induced cell death signaling pathway. Mitochondrial calpain plays important roles both in caspase-dependent and -independent pathways in cell death phenomena. Mu-calpain can act as a direct activator of apoptosis-inducing factor release in neuronal cultures challenged with oxygen-glucose deprivation | Rattus norvegicus |