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Literature summary for 3.4.22.52 extracted from

  • Guttmann, R.P.; Baker, D.L.; Seifert, K.M.; Cohen, A.S.; Coulter, D.A.; Lynch, D.R.
    Specific proteolysis of the NR2 subunit at multiple sites by calpain (2001), J. Neurochem., 78, 1083-1093.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Sus scrofa
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NR2 subunit of NMDA subtype of glutamate receptor + H2O all three subtypes of NR2 subunits can be proteolyzed, cleavage of NR2A, NR2B and NR2C subunits is limited to their C-terminal region. Two cleavage sites at amino acids 1279 and 1330. Cleavage of NR2A-containing receptors does not alter basic NMDA receptor properties including calcium uptake, MK801 binding or electrophysiological measurement Sus scrofa ?
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