Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.22.51 extracted from

  • Merlino, A.; Benitez, D.; Campillo, N.; Páez, J.; Tinoco, L.; González, M.; Cerecetto, H.
    Amidines bearing benzofuroxan or benzimidazole 1,3-dioxide core scaffolds as Trypanosoma cruzi-inhibitors: Structural basis for their interactions with cruzipain (2012), MedChemComm, 3, 90-101.
No PubMed abstract available
Search for more literature for 3.4.22.51

Inhibitors

Inhibitors Comment Organism Structure
(2E)-2-{4-[(3-oxido-2,1,3-benzoxadiazol-5-yl)methoxy]benzylidene}hydrazinecarboximidamide
-
 Trypanosoma cruzi
(3-oxido-2,1,3-benzoxadiazol-5-yl)methyl (2E)-2-(4-hydroxybenzylidene)hydrazinecarbimidothioate
-
 Trypanosoma cruzi
(m-bromophenyl)ethylketone thiosemicarbazone
-
 Trypanosoma cruzi
2,2-dimethyl-5-[4-(N-phenyl-N'-phenylethyl)amidinopiperazin-1-ylmethyl]-2H-benzimidazole 1,3-di-N-oxide
-
 Trypanosoma cruzi
5-[4-(N,N'-diphenyl)amidinopiperazin-1-ylmethyl]benzo[1,2-c]1,2,5-oxadiazole N-oxide
-
 Trypanosoma cruzi
5-[4-(N-benzyl-N'-phenyl)amidinopiperazin-1-ylmethyl]-2,2-dimethyl-2H-benzimidazole 1,3-di-N-oxide
-
 Trypanosoma cruzi
5-[4-(N-benzyl-N'-phenyl)amidinopiperazin-1-ylmethyl]benzo[1,2-c]1,2,5-oxadiazole N-oxide
-
 Trypanosoma cruzi
5-[4-(N-furyl-N'-phenyl)amidinopiperazin-1-ylmethyl]-2,2-dimethyl-2H-benzimidazole 1,3-di-N-oxide
-
 Trypanosoma cruzi
5-[4-(N-furyl-N'-phenyl)amidinopiperazin-1-ylmethyl]benzo[1,2-c]1,2,5-oxadiazole N-oxide
-
 Trypanosoma cruzi
5-[4-(N-phenyl-N'-phenylethyl)amidinopiperazin-1-yl methyl]benzo[1,2-c]1,2,5-oxadiazole N-oxide
-
 Trypanosoma cruzi
6-[(E)-2-(phenylsulfonyl)ethenyl]-2,1,3-benzoxadiazole 1-oxide
-
 Trypanosoma cruzi
Amphotericin B
-
 Trypanosoma cruzi
Bnz
-
 Trypanosoma cruzi
E-64
-
 Trypanosoma cruzi
additional information 0.01% (v/v) of Triton X-100 does not interfere with enzyme activity Trypanosoma cruzi
N'-(furan-2-ylmethyl)-N-phenylpiperazine-1-carboximidamide 10% inhibition at 0.1 mM, at pH 5.3, temperature not specified in the publication Trypanosoma cruzi
N'-benzyl-N-phenylpiperazine-1-carboximidamide 5.4% inhibition at 0.1 mM, at pH 5.3, temperature not specified in the publication Trypanosoma cruzi
N,N'-diphenylpiperazine-1-carboximidamide 6.3% inhibition at 0.1 mM, at pH 5.3, temperature not specified in the publication Trypanosoma cruzi
N-phenyl-N'-(2-phenylethyl)piperazine-1-carboximidamide 3.2% inhibition at 0.1 mM, at pH 5.3, temperature not specified in the publication Trypanosoma cruzi
Nfx
-
 Trypanosoma cruzi
Triton X-100 non-specific inhibition in the presence of 0.02% (v/v) Triton X-100 Trypanosoma cruzi
VS4
-
 Trypanosoma cruzi

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Hemoglobin + H2O Trypanosoma cruzi
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Trypanosoma cruzi
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Hemoglobin + H2O
-
 Trypanosoma cruzi ?
-
 ?
Z-Phe-Arg-7-amido-4-methylcoumarin + H2O
-
 Trypanosoma cruzi Z-Phe-Arg + 7-amino-4-methylcoumarin
-
 ?