Literature summary for 3.4.22.51 extracted from

dos Reis, F.C.; Smith, B.O.; Santos, C.C.; Costa, T.F.; Scharfstein, J.; Coombs, G.H.; Mottram, J.C.; Lima, A.P.
The role of conserved residues of chagasin in the inhibition of cysteine peptidases (2008), FEBS Lett., 582, 485-490.

Search for more literature for 3.4.22.51

Inhibitors

Inhibitors	Comment	Organism	Structure
chagasin	-	Trypanosoma cruzi
chagasin mutant delta T31-T32	-	Trypanosoma cruzi
chagasin mutant P30A	-	Trypanosoma cruzi
chagasin mutant T31A	-	Trypanosoma cruzi
chagasin mutant T31A/T32A	-	Trypanosoma cruzi
chagasin mutant T31S	-	Trypanosoma cruzi
chagasin mutant T31V	-	Trypanosoma cruzi
chagasin mutant T31Y	-	Trypanosoma cruzi
chagasin mutant T32A	-	Trypanosoma cruzi
chagasin mutant T32E	-	Trypanosoma cruzi
chagasin mutant T32S	-	Trypanosoma cruzi
chagasin mutant T32V	-	Trypanosoma cruzi
chagasin mutant T32Y	-	Trypanosoma cruzi
chagasin mutant W93A	-	Trypanosoma cruzi
chagasin mutant Y89F	-	Trypanosoma cruzi
chagasin mutant Y89S	-	Trypanosoma cruzi

Organism

Organism	UniProt	Comment	Textmining
Trypanosoma cruzi	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Z-Phe-Arg-7-amido-4-methylcoumarin + H2O	5 microM, pH 6.5, 28°C	Trypanosoma cruzi	?	-	?

Synonyms

Synonyms	Comment	Organism
cruzipain	-	Trypanosoma cruzi
family C1 cysteine peptidase	-	Trypanosoma cruzi

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
28	-	assay at pH 6.5	Trypanosoma cruzi

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
6.5	-	assay at 28°C	Trypanosoma cruzi

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0000000076	-	chagasin	-	Trypanosoma cruzi
0.000000011	-	chagasin mutant T31S	-	Trypanosoma cruzi
0.000000011	-	chagasin mutant T32E	-	Trypanosoma cruzi
0.000000016	-	chagasin mutant T32A	-	Trypanosoma cruzi
0.000000016	-	chagasin mutant T32Y	-	Trypanosoma cruzi
0.00000002	-	chagasin mutant P30A	-	Trypanosoma cruzi
0.00000002	-	chagasin mutant T32S	-	Trypanosoma cruzi
0.00000002	-	chagasin mutant Y89F	-	Trypanosoma cruzi
0.000000025	-	chagasin mutant Y89S	-	Trypanosoma cruzi
0.000000031	-	chagasin mutant W93A	-	Trypanosoma cruzi
0.00000007	-	chagasin mutant T31V	-	Trypanosoma cruzi
0.000000193	-	chagasin mutant T32V	-	Trypanosoma cruzi
0.000000317	-	chagasin mutant T31A	-	Trypanosoma cruzi
0.000000747	-	chagasin mutant T31Y	-	Trypanosoma cruzi
0.000001065	-	chagasin mutant T31A/T32A	-	Trypanosoma cruzi
0.000005868	-	chagasin mutant deltaT31-T32	-	Trypanosoma cruzi

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Release 2023.1 (January 2023)