BRENDA - Reference to 3.4.22.51; Id = 638876

0.0011

-

benzyloxycarbonyl-FR-aminomethyl coumarin

pH 6.3, 37°C

Trypanosoma cruzi

0.0012

-

benzoyl-FR-aminomethyl coumarin

pH 6.3, 37°C

Trypanosoma cruzi

0.0119

-

benzoyl-RR-aminomethyl coumarin

pH 6.3, 37°C

Trypanosoma cruzi

0.043

-

benzoyl-HR-aminomethyl coumarin

pH 6.3, 37°C

Trypanosoma cruzi

Q598P5

-

benzoyl-FR-4-methylcoumarin 7-amide + H2O

fluorigenic substrates based on this peptide, substitution of Phe results in less susceptible substrates

638876

Trypanosoma cruzi

?

-

?

benzoyl-HR-4-methylcoumarin 7-amide + H2O

less susceptible substrate

638876

Trypanosoma cruzi

?

-

?

benzoyl-Phe-Arg-4-methylcoumarin-7-amide + H2O

fluorogenic substrates based on the peptide benzoyl-Phe-Arg-4-methylcoumarin-7-amide

638876

Trypanosoma cruzi

?

-

?

benzoyl-RR-4-methylcoumarin 7-amide + H2O

less susceptible substrate

638876

Trypanosoma cruzi

?

-

?

benzyloxycarbonyl-Phe-Arg-4-methylcoumarin 7-amide + H2O

-

638876

Trypanosoma cruzi

?

-

?

37

-

assay at

Trypanosoma cruzi

0.0783

-

benzoyl-RR-aminomethyl coumarin

-

Trypanosoma cruzi

0.158

-

benzyloxycarbonyl-FR-aminomethyl coumarin

-

Trypanosoma cruzi

0.172

-

benzoyl-HR-aminomethyl coumarin

-

Trypanosoma cruzi

0.193

-

benzoyl-FR-aminomethyl coumarin

-

Trypanosoma cruzi

0.0011

-

benzyloxycarbonyl-FR-aminomethyl coumarin

pH 6.3, 37°C

Trypanosoma cruzi

0.0012

-

benzoyl-FR-aminomethyl coumarin

pH 6.3, 37°C

Trypanosoma cruzi

0.0119

-

benzoyl-RR-aminomethyl coumarin

pH 6.3, 37°C

Trypanosoma cruzi

0.043

-

benzoyl-HR-aminomethyl coumarin

pH 6.3, 37°C

Trypanosoma cruzi

benzoyl-FR-4-methylcoumarin 7-amide + H2O

fluorigenic substrates based on this peptide, substitution of Phe results in less susceptible substrates

638876

Trypanosoma cruzi

?

-

?

benzoyl-HR-4-methylcoumarin 7-amide + H2O

less susceptible substrate

638876

Trypanosoma cruzi

?

-

?

benzoyl-Phe-Arg-4-methylcoumarin-7-amide + H2O

fluorogenic substrates based on the peptide benzoyl-Phe-Arg-4-methylcoumarin-7-amide

638876

Trypanosoma cruzi

?

-

?

benzoyl-RR-4-methylcoumarin 7-amide + H2O

less susceptible substrate

638876

Trypanosoma cruzi

?

-

?

benzyloxycarbonyl-Phe-Arg-4-methylcoumarin 7-amide + H2O

-

638876

Trypanosoma cruzi

?

-

?

37

-

assay at

Trypanosoma cruzi

0.0783

-

benzoyl-RR-aminomethyl coumarin

-

Trypanosoma cruzi

0.158

-

benzyloxycarbonyl-FR-aminomethyl coumarin

-

Trypanosoma cruzi

0.172

-

benzoyl-HR-aminomethyl coumarin

-

Trypanosoma cruzi

0.193

-

benzoyl-FR-aminomethyl coumarin

-

Trypanosoma cruzi

752406

Barbosa da Silva

Cruzain structures apocruzain ...

Trypanosoma cruzi

Acta Crystallogr. Sect. F

75

419-427

2019

-

1

-

1

-

3

-

1

-

1

-

1

-

1

-

1

-

1

-

753013

Fabian

Evaluation of quinoxaline com ...

Trypanosoma cruzi

Bioorg. Med. Chem. Lett.

29

2197-2202

2019

-

1

-

1

-

1

-

1

-

753923

Reyes-Espinosa

In silico analysis of homolog ...

Trypanosoma cruzi

Int. J. Mol. Sci.

20

E1320

2019

-

4

-

1

-

4

-

753924

Herrera-Mayorga

Structure-based virtual scree ...

Trypanosoma cruzi, Trypanosoma cruzi INC-5

Int. J. Mol. Sci.

20

E1742

2019

-

4

-

3

-

2

-

2

-

1

-

4

-

4

-

2

-

2

-

1

-

752781

Zhai

Catalytic mechanism of cruzai ...

Trypanosoma cruzi

Biochemistry

57

3176-3190

2018

-

1

-

1

31

-

2

-

1

-

3

-

24

-

1

-

1

-

31

-

1

-

3

-

24

-

27

752931

Cianni

Leveraging the cruzain S3 sub ...

Trypanosoma cruzi

Bioorg. Chem.

79

285-292

2018

-

10

-

2

-

1

-

10

-

1

-

755010

Dos Santos

Experimental study and comput ...

Trypanosoma cruzi

Phys. Chem. Chem. Phys.

20

24317-24328

2018

-

1

-

7

-

2

-

1

-

1

-

1

-

7

-

1

-

1

-

752755

Arafet

First quantum mechanics/molec ...

Trypanosoma cruzi

Biochemistry

54

3381-3391

2015

-

1

-

2

-

2

-

1

-

1

-

2

-

1

-

753481

Espindola

Synthesis and structure-activ ...

Trypanosoma cruzi

Eur. J. Med. Chem.

101

818-835

2015

-

32

-

2

-

1

-

1

-

4

-

4

32

-

1

-

755082

Ferrao

Cruzipain activates latent TG ...

Trypanosoma cruzi

PLoS ONE

10

e0124832

2015

-

1

-

1

-

2

-

1

-

1

-

1

-

1

-

732453

Merlino

-

Amidines bearing benzofuroxan ...

Trypanosoma cruzi

MedChemComm

3

90-101

2012

-

22

-

1

-

1

-

2

-

22

-

1

-

2

-

732673

Uehara

Cruzipain promotes Trypanosoma ...

Trypanosoma cruzi, Trypanosoma cruzi Dm28c

PLoS Negl. Trop. Dis.

6

e1958

2012

-

7

-

1

-

6

-

3

-

7

-

1

-

3

-

1

-

717475

Pizzo

Synthesis of 2-hydrazolyl-4-th ...

Trypanosoma cruzi

Chem. Biol. Drug Des.

77

166-172

2011

-

19

-

2

-

1

-

1

-

1

-

1

-

19

-

1

-

1

-

1

-

1

-

718182

Acosta

A striking common O-linked N-a ...

Trypanosoma cruzi

Parasite Immunol.

33

363-370

2011

-

3

-

4

-

1

-

1

-

3

-

1

-

1

-

1

-

718307

Doyle

The Trypanosoma cruzi protease ...

Trypanosoma cruzi

PLoS Pathog.

7

e1002139

2011

-

1

-

1

-

1

-

2

-

1

-

1

-

1

-

1

-

1

-

2

-

717894

Borchhardt

-

Biochemical evaluation of a se ...

Trypanosoma cruzi

J. Braz. Chem. Soc.

21

142-150

2010

-

1

-

41

-

1

-

1

-

1

-

1

-

40

-

1

-

40

41

-

1

-

1

-

1

-

717917

Trossini

Cruzain inhibition by hydroxym ...

Trypanosoma cruzi

J. Enzyme Inhib. Med. Chem.

25

62-67

2010

-

4

-

2

-

1

-

1

-

1

-

2

-

2

4

-

1

-

1

-

1

-

718066

Trossini

-

Molecular modeling suggests cr ...

Trypanosoma cruzi

Lett. Drug Des. Discov.

7

528-533

2010

-

1

-

4

-

1

-

5

-

1

-

1

-

4

-

5

-

696760

Romeiro

Synthesis, trypanocidal activi ...

Trypanosoma cruzi, Trypanosoma cruzi Tulahuen 2

Bioorg. Med. Chem.

17

641-652

2009

-

1

-

17

-

1

-

6

-

1

-

3

-

1

-

3

17

-

1

-

700567

Pereira

Cysteine peptidases in Herpeto ...

Trypanosoma cruzi, Trypanosoma cruzi Dm28c

Parasitology

136

45-54

2009

-

2

-

8

-

1

-

2

-

710673

Huson

Modulation of the immunogenici ...

Trypanosoma congolense

Vet. Res.

40

52

2009

-

1

-

4

-

1

-

1

-

1

-

1

-

1

-

1

-

710780

Ortiz

Genes of cathepsin L-like prot ...

Trypanosoma rangeli

Acta Trop.

112

249-259

2009

-

1

-

1

-

1

7

-

7

-

14

-

7

-

7

-

7

-

7

-

14

-

713023

Cortez

Cathepsin L-like genes of Tryp ...

Trypanosoma vivax

Mol. Cell. Probes

23

44-51

2009

-

2

-

4

-

677418

Stempin

Cruzipain and SP600125 induce ...

Trypanosoma cruzi

Acta Trop.

106

119-127

2008

-

1

-

3

-

2

-

2

-

1

-

2

-

696523

Scharfstein

Angiotensin-converting enzyme ...

Trypanosoma cruzi

Biol. Chem.

389

1015-1024

2008

1

-

2

-

2

-

4

-

4

-

1

-

1

-

2

-

2

-

1

-

696645

Chen

Synthesis of macrocyclic trypa ...

Trypanosoma brucei rhodesiense, Trypanosoma cruzi

Bioorg. Med. Chem. Lett.

18

5860-5863

2008

-

7

-

3

-

2

-

2

-

6

-

6

7

-

2

-

696710

Zanatta

Convergent synthesis and cruza ...

Trypanosoma cruzi

Bioorg. Med. Chem.

16

10236-10243

2008

-

1

-

28

-

1

-

1

-

1

-

9

-

1

-

9

28

-

1

-

1

-

696729

Porcal

New trypanocidal hybrid compou ...

Trypanosoma cruzi, Trypanosoma cruzi Tulahuen 2

Bioorg. Med. Chem.

16

6995-7004

2008

-

10

-

8

-

1

-

2

-

1

-

9

-

9

10

-

1

-

1

-

697814

Elias

Cysteine peptidases in the tom ...

Trypanosoma cruzi, Trypanosoma cruzi Dm28c

Exp. Parasitol.

120

343-352

2008

-

1

-

9

-

1

-

1

-

697939

dos Reis

The role of conserved residues ...

Trypanosoma cruzi

FEBS Lett.

582

485-490

2008

-

16

-

3

-

1

-

2

1

-

1

-

16

-

16

-

1

-

1

-

1

-

698164

SantAnna

All Trypanosoma cruzi developm ...

Trypanosoma cruzi, Trypanosoma cruzi Y

Histochem. Cell Biol.

130

1187-1198

2008

-

1

-

2

-

12

-

1

-

1

-

3

-

1

-

2

-

1

-

1

-

698293

Acosta

Sulfates are main targets of i ...

Trypanosoma cruzi, Trypanosoma cruzi Tulahuen 2

Int. Immunol.

20

461-470

2008

-

1

-

7

-

1

-

1

-

2

-

1

-

1

-

1

-

698473

Brak

Identification of a new class ...

Trypanosoma cruzi

J. Am. Chem. Soc.

130

6404-6410

2008

-

7

-

3

-

21

-

1

-

7

-

21

-

699388

Fricker

Metal compounds for the treatm ...

Trypanosoma cruzi

J. Inorg. Biochem.

102

1839-1845

2008

-

6

1

-

5

-

1

-

1

-

1

-

1

-

6

-

6

-

1

-

1

-

1

-

1

-

1

-

700564

Fampa

Protease expression analysis i ...

Trypanosoma cruzi

Parasitology

135

1093-1100

2008

-

2

-

1

-

2

-

1

-

3

-

2

-

1

-

1

-

700875

Abdulla

RNA interference of Trypanosom ...

Trypanosoma brucei

PLoS Negl. Trop. Dis.

2

e298

2008

-

1

-

1

-

2

-

6

-

2

-

1

-

1

-

1

-

2

-

2

-

701365

Cazorla

Prime-boost immunization with ...

Trypanosoma cruzi, Trypanosoma cruzi RA

Vaccine

26

1999-2009

2008

-

1

-

1

-

5

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

679761

Reis

The propeptide of cruzipain--a ...

Trypanosoma cruzi

FEBS J.

274

1224-1234

2007

-

1

-

1

-

1

-

5

-

1

-

1

-

1

-

1

-

5

-

1

-

1

5

-

1

-

1

-

1

-

1

-

679892

dos Reis

The substrate specificity of c ...

Trypanosoma cruzi

FEMS Microbiol. Lett.

259

215-220

2006

-

21

-

3

-

21

-

1

-

21

1

-

21

-

21

-

1

-

21

1

-

667653

Polticelli

Probing the cruzain S2 recogni ...

Trypanosoma cruzi

Biochemistry

44

2781-2789

2005

-

3

-

2

-

1

-

3

-

3

-

3

-

1

-

3

-

3

-

667951

Fujii

Discovery of potent thiosemica ...

Trypanosoma cruzi

Bioorg. Med. Chem. Lett.

15

121-123

2005

-

10

-

4

-

1

-

10

-

10

-

668551

Barboza

Structural analysis of the N-g ...

Trypanosoma cruzi

FEBS J.

272

3803-3815

2005

-

3

-

1

-

1

-

667144

Aoki

Cruzipain, a major Trypanosoma ...

Trypanosoma cruzi

Am. J. Physiol.

286

C206-C212

2004

-

1

-

3

-

1

-

1

-

1

-

668458

Judice

Carboxydipeptidase activities ...

Trypanosoma cruzi

Eur. J. Biochem.

271

1046-1053

2004

-

7

-

7

-

7

-

7

2

-

7

-

7

-

7

2

-

638890

Sterin-Borda

Cruzipain induces autoantibodi ...

Trypanosoma cruzi

Eur. J. Immunol.

33

2459-2468

2003

-

1

-

2

-

1

-

2

-

1

-

1

-

1

-

2

-

1

-

667936

Chiyanzu

Synthesis and evaluation of is ...

Trypanosoma cruzi

Bioorg. Med. Chem. Lett.

13

3527-3530

2003

-

16

-

1

-

16

-

16

-

668522

Duschak

Trypanosoma cruzi: partial cha ...

Trypanosoma cruzi

Exp. Parasitol.

104

122-130

2003

-

1

-

1

-

3

-

1

-

10

1

2

-

1

-

1

-

1

-

10

1

-

670178

Barboza

Presence of sialic acid in N-l ...

Trypanosoma cruzi

Mol. Biochem. Parasitol.

127

69-72

2003

-

2

-

1

-

1

-

670179

Berasain

Specific cleavage sites on hum ...

Trypanosoma cruzi

Mol. Biochem. Parasitol.

130

23-29

2003

-

3

-

1

-

1

-

638875

Alvarez

Expression in insect cells of ...

Trypanosoma cruzi

Protein Expr. Purif.

26

467-475

2002

-

1

-

2

-

2

-

1

-

1

-

3

-

1

2

-

1

-

1

-

2

-

1

-

1

-

3

-

1

2

-

638884

Lalmanach

Congopain from Trypanosoma con ...

Trypanosoma congolense

Biol. Chem.

383

739-749

2002

3

-

3

-

1

-

5

-

1

-

2

-

1

-

1

-

3

-

3

1

-

1

-

1

-

2

-

1

-

638885

Lima

Heparan sulfate modulates kini ...

Trypanosoma cruzi

J. Biol. Chem.

277

5875-5881

2002

-

2

-

2

-

1

-

2

-

1

-

2

-

2

-

2

-

1

-

2

-

1

-

2

-

638887

Ramos

Trypanosoma cruzi: cruzipain a ...

Trypanosoma cruzi

Exp. Parasitol.

100

121-130

2002

-

2

-

3

-

1

-

1

-

2

-

1

-

1

-

638889

Schnapp

Cruzipain induces both mucosal ...

Trypanosoma cruzi

Infect. Immun.

70

5065-5074

2002

-

1

-

1

-

5

-

1

-

2

-

1

-

1

-

1

-

1

-

2

-

1

-

638876

Alves

Analysis of the S2 subsite spe ...

Trypanosoma cruzi

Mol. Biochem. Parasitol.

117

137-143

2001

-

4

-

3

-

5

-

1

-

4

-

4

-

5

-

1

-

4

-

638883

Judice

Comparison of the specificity, ...

Trypanosoma cruzi

Eur. J. Biochem.

268

6578-6586

2001

-

4

-

1

-

2

-

1

-

5

-

1

-

4

1

-

4

-

1

-

1

-

5

-

1

-

4

1

-

638888

Salvati

Modulation of the catalytic ac ...

Trypanosoma cruzi

Eur. J. Biochem.

268

3253-3258

2001

-

2

4

-

2

-

2

-

4

-

2

4

-

2

-

638891

Stoka

The high stability of cruzipai ...

Trypanosoma cruzi

FEBS Lett.

469

29-32

2000

-

1

-

1

-

1

-

2

-

1

-

1

-

2

-

638879

Cazzulo

Cruzipain, the major cysteine ...

Trypanosoma cruzi

Biol. Chem.

378

1-10

1997

1

-

1

-

13

2

1

-

5

-

3

-

1

-

19

-

1

-

1

-

1

-

1

-

1

-

13

-

2

1

-

5

-

1

-

19

-

1

-

1

-

638880

Del Nery

-

Characterization of the substr ...

Trypanosoma cruzi

Biochem. J.

323

427-433

1997

-

1

-

2

-

1

-

1

-

2

-

1

-

1

-

638882

Gillmor

Structural determinants of spe ...

Trypanosoma cruzi

Protein Sci.

6

1603-1611

1997

-

1

-

2

-

2

-

1

-

1

-

2

-

1

-

638877

Cazzulo

Hydrolysis of synthetic peptid ...

Trypanosoma cruzi

Cell. Mol. Biol.

42

691-696

1996

-

2

-

2

-

4

-

1

-

2

-

4

-

1

-

638886

McGrath

The crystal structure of cruza ...

Trypanosoma cruzi

J. Mol. Biol.

247

251-259

1995

-

1

-

2

-

2

-

1

-

1

-

2

-

1

-

638881

Eakin

Production of crystallizable c ...

Trypanosoma cruzi

J. Biol. Chem.

268

6115-6118

1993

-

1

2

-

2

-

1

-

4

-

1

-

1

-

3

-

1

2

-

1

-

1

2

-

2

-

1

-

1

-

1

-

3

-

1

2

-

638892

Cazzulo

On the post-translational modi ...

Trypanosoma cruzi

FEMS Microbiol. Lett.

79

411-416

1992

-

2

-

1

-

1

-

638878

Cazzulo

Some kinetic properties of a c ...

Trypanosoma cruzi

Biochim. Biophys. Acta

1037

186-191

1990

3

-

1

4

1

-

2

-

1

-

1

2

-

6

-

1

3

-

1

-

3

-

1

-

4

-

1

-

2

-

1

2

-

6

-

1

3

-

1

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Analysis of the S2 subsite specificities of the recombinant cysteine proteinases CPB of Leishmania mexicana, and cruzain of Trypanosoma cruzi, using fluorescent substrates containing non-natural basic amino acids

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