Activating Compound | Comment | Organism | Structure |
---|---|---|---|
cyclinB1 | - |
Homo sapiens | |
imatinib | activation of separase proteolytic activity occurs exclusively in BCR-ABL-positive cells during imatinib treatment (0.00025-0.01 mM for 24 h) | Homo sapiens | |
PP2A | - |
Homo sapiens | |
securing | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
centrosome | - |
Homo sapiens | 5813 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cohesin + H2O | Homo sapiens | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q14674 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | the enzyme is phosphorylated at serine residue 1126 | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | - |
Homo sapiens | - |
HL-60 cell | - |
Homo sapiens | - |
K-562 cell | - |
Homo sapiens | - |
LAMA-84 cell | - |
Homo sapiens | - |
U-937 cell | - |
Homo sapiens | - |
urothelial cell | - |
Homo sapiens | - |
UROtsa cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cohesin + H2O | - |
Homo sapiens | ? | - |
? |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | decreased separase protein levels are observed in BCR-ABL-positive and -negative cells treated with imatinib in a dose dependent manner | down |
General Information | Comment | Organism |
---|---|---|
physiological function | separase is required for the separation of sister-chromatides in mitotic anaphase, triggers centriole disengagement during centrosome duplication. In cancer, separase is frequently overexpressed, pointing to a functional role as an aneuploidy promoter associated with centrosomal amplification and genomic instability | Homo sapiens |