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Literature summary for 3.4.22.49 extracted from

  • Haass, W.; Stehle, M.; Nittka, S.; Giehl, M.; Schrotz-King, P.; Fabarius, A.; Hofmann, W.K.; Seifarth, W.
    The proteolytic activity of separase in BCR-ABL-positive cells is increased by imatinib (2012), PLoS ONE, 7, e42863.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
cyclinB1
-
Homo sapiens
imatinib activation of separase proteolytic activity occurs exclusively in BCR-ABL-positive cells during imatinib treatment (0.00025-0.01 mM for 24 h) Homo sapiens
PP2A
-
Homo sapiens
securing
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
centrosome
-
Homo sapiens 5813
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cohesin + H2O Homo sapiens
-
?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q14674
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein the enzyme is phosphorylated at serine residue 1126 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
-
Homo sapiens
-
HL-60 cell
-
Homo sapiens
-
K-562 cell
-
Homo sapiens
-
LAMA-84 cell
-
Homo sapiens
-
U-937 cell
-
Homo sapiens
-
urothelial cell
-
Homo sapiens
-
UROtsa cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cohesin + H2O
-
Homo sapiens ?
-
?

Expression

Organism Comment Expression
Homo sapiens decreased separase protein levels are observed in BCR-ABL-positive and -negative cells treated with imatinib in a dose dependent manner down

General Information

General Information Comment Organism
physiological function separase is required for the separation of sister-chromatides in mitotic anaphase, triggers centriole disengagement during centrosome duplication. In cancer, separase is frequently overexpressed, pointing to a functional role as an aneuploidy promoter associated with centrosomal amplification and genomic instability Homo sapiens