Cloned (Comment) | Organism |
---|---|
expressed in HeLa cells | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
S1121A | nonphosphorylatable mutant | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
cyclin B1 | - |
Mus musculus | |
sercurin | securin persistently binds and inhibits separase during much of metaphase | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
chromosome | - |
Mus musculus | 5694 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cohesin + H2O | Mus musculus | chromatin-bound cohesion is the preferential substrate | ? | - |
? | |
Scc1 + H2O | Mus musculus | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P60330 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | - |
Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cohesin + H2O | chromatin-bound cohesion is the preferential substrate | Mus musculus | ? | - |
? | |
Scc1 + H2O | - |
Mus musculus | ? | - |
? |
General Information | Comment | Organism |
---|---|---|
physiological function | binding between separase and cyclin B1 is required for the anaphase movement of unpaired sister chromatids. Separase promotes the reversal of Cdk1-mediated phosphorylation on chromosomes at anaphase onset | Mus musculus |