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Literature summary for 3.4.22.49 extracted from

  • Shindo, N.; Kumada, K.; Hirota, T.
    Separase sensor reveals dual roles for separase coordinating cohesin cleavage and cdk1 inhibition (2012), Dev. Cell, 23, 112-123.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HeLa cells Mus musculus

Protein Variants

Protein Variants Comment Organism
S1121A nonphosphorylatable mutant Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
cyclin B1
-
Mus musculus
sercurin securin persistently binds and inhibits separase during much of metaphase Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
chromosome
-
Mus musculus 5694
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cohesin + H2O Mus musculus chromatin-bound cohesion is the preferential substrate ?
-
?
Scc1 + H2O Mus musculus
-
?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus P60330
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein
-
Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cohesin + H2O chromatin-bound cohesion is the preferential substrate Mus musculus ?
-
?
Scc1 + H2O
-
Mus musculus ?
-
?

General Information

General Information Comment Organism
physiological function binding between separase and cyclin B1 is required for the anaphase movement of unpaired sister chromatids. Separase promotes the reversal of Cdk1-mediated phosphorylation on chromosomes at anaphase onset Mus musculus