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Literature summary for 3.4.22.49 extracted from
- Regulation of the anaphase-promoting complex-separase cascade by transforming growth factor-beta modulates mitotic progression in bone marrow stromal cells (2008), Mol. Biol. Cell, 19, 5446-5455.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| enhanced cyclin-dependent kinase 1 activity due to deregulation of CDC27-anaphase-promoting complex leads in turn to hyperphosphorylation of Separase, impeding chromatid separation. Regulation of mitotic progression by transforming growth factor-beta in bone marrow stromal cells is through targeting the APC-separase pathway | Mus musculus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| S1126A | specifically abolished separase hyperphosphorylation in Smad3-deficient cells | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| bone marrow stromal cell line | - |
Mus musculus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| separase | - |
Mus musculus |
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Release 2023.1 (January 2023)
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