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Literature summary for 3.4.22.49 extracted from

  • Gorr, I.H.; Reis, A.; Boos, D.; Wuehr, M.; Madgwick, S.; Jones, K.T.; Stemmann, O.
    Essential CDK1-inhibitory role for separase during meiosis I in vertebrate oocytes (2006), Nat. Cell Biol., 8, 1035-1037.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.49

Protein Variants

Protein Variants Comment Organism
additional information it is shown that separase acts as a direct inhibitor of cyclin-dependent kinase 1 on liberation from the inhibitory protein securin. Blocking separase-cyclin-dependent kinase 1 complex formation by microinjection of anti-separase antibodies prevents polar-body extrusion in vertebrate oocytes Xenopus laevis
S1138A mutant containing phosphorylation site mutation compromises Cdk1-inhibitory ability Xenopus laevis
S1139A mutant containing phosphorylation site mutation compromises Cdk1-inhibitory ability Xenopus laevis

Organism

Organism UniProt Comment Textmining
Xenopus laevis
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein
-
 Xenopus laevis

Source Tissue

Source Tissue Comment Organism Textmining
oocyte
-
 Xenopus laevis
-

Synonyms

Synonyms Comment Organism
separase
-
 Xenopus laevis