Literature summary for 3.4.22.49 extracted from

Zou, H.; Stemman, O.; Anderson, J.S.; Mann, M.; Kirschner, M.W.
Anaphase specific auto-cleavage of separase (2002), FEBS Lett., 528, 246-250.

Search for more literature for 3.4.22.49

Cloned(Commentary)

Cloned (Comment)	Organism
expression of myc6-separase in 293T cells	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
R1486A	mutation fails to block autocatalytical cleavage	Homo sapiens
R1506A	mutation at autocatalytical cleavage site, mutant enzyme is still cleaved indicating the existence of a second cleavage site	Homo sapiens
R1506A/R1486A	mutation fails to block autocatalytical cleavage	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
proteolytic modification	separase is subjected to auto-catalytic proteolytic cleavage at 3 adjacent sites, cleavage occurs specifically at anaphase coincident with separase activation, cleavage has no effect on in vitro activity	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
HeLa-S3 cell	-	Homo sapiens	-

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Release 2023.1 (January 2023)