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Literature summary for 3.4.22.48 extracted from
- Degradation of fibrinogen and collagen by staphopains, cysteine proteases released from Staphylococcus aureus (2011), Microbiology, 157, 786-792.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Staphylococcus aureus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Collagen + H2O | - |
Staphylococcus aureus | ? | - |
? |  |
| fibrinogen A alpha chain + H2O | rather slow degradation through Sscp A | Staphylococcus aureus | ? | - |
? | |
| fibrinogen A alpha chain + H2O | Sscp B cleaves the fibrinogen A alpha-chain at the C-terminal region very efficiently | Staphylococcus aureus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Sscp A | - |
Staphylococcus aureus |
| Sscp B | - |
Staphylococcus aureus |
| staphopain A | - |
Staphylococcus aureus |
| staphopain B | - |
Staphylococcus aureus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 35 | - |
assay at | Staphylococcus aureus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | both staphopains (staphopain A and staphopain B) prolong the partial thromboplastin time of plasma in a dose- and activity-dependent manner, with SspB being 3fold more potent than ScpA. Staphopains also prolong the thrombin time of both plasma and fibrinogen, indicating that these enzymes can cause impaired plasma clotting through fibrinogen degradation | Staphylococcus aureus |
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