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Literature summary for 3.4.22.47 extracted from
- Porphyromonas gingivalis mediates the shedding and proteolysis of complement regulatory protein CD46 expressed by oral epithelial cells (2009), Oral Microbiol. Immunol., 24, 396-400.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| tosyl-Lys-chloromethylketone | - |
Porphyromonas gingivalis |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Porphyromonas gingivalis | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| Lys-gingipain is purified from the cell envelope extract of Porphyromonas gingivalis KDP112 by affinity chromatography on arginine Sepharose 4B | Porphyromonas gingivalis |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CD46 + H2O | recombinant CD46 is degraded by Lys-gingipain in a dose-dependent manner | Porphyromonas gingivalis | ? | - |
? | |
| N-4-tosyl-Gly-Pro-Lys-4-nitroanilide + H2O | - |
Porphyromonas gingivalis | N-4-tosyl-Gly-Pro-Lys + 4-nitroaniline | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| KGP | - |
Porphyromonas gingivalis |
| Lys-gingipain | - |
Porphyromonas gingivalis |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Porphyromonas gingivalis |
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Release 2023.1 (January 2023)
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