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Literature summary for 3.4.22.47 extracted from

  • Nhien, N.T.; Huy, N.T.; Naito, M.; Oida, T.; Uyen, D.T.; Huang, M.; Kikuchi, M.; Harada, S.; Nakayama, K.; Hirayama, K.; Kamei, K.
    Neutralization of toxic haem by Porphyromonas gingivalis haemoglobin receptor (2010), J. Biochem., 147, 317-325.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
HbR domain is recombinantly expressed in Escherichia coli Porphyromonas gingivalis

Organism

Organism UniProt Comment Textmining
Porphyromonas gingivalis
-
-
-

Synonyms

Synonyms Comment Organism
gingipain
-
Porphyromonas gingivalis
HbR adhesin domain of gingipain which is able to bind heme as an iron nutrient source for Porphyromonas gingivalis Porphyromonas gingivalis

General Information

General Information Comment Organism
physiological function using erythrocyte and its membrane as a model, it is shown that recombinant HbR expressed in Escherichia coli can inhibit heme-induced haemolysis, probably through removing heme from the heme-membrane complex and lowering free heme toxicity by mediating dimerization of heme molecules Porphyromonas gingivalis