Inhibitors | Comment | Organism | Structure |
---|---|---|---|
zFKck | human gingvial epithelial cells treated with Kgp-specific inhibitor leupeptin and challenged with Porphyromonas gingivalis cells do not undergo apoptosis | Porphyromonas gingivalis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Porphyromonas gingivalis | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
KGP | - |
Porphyromonas gingivalis |
Lys-gingipain | - |
Porphyromonas gingivalis |
General Information | Comment | Organism |
---|---|---|
malfunction | Porphyromonas gingivalis triple mutant RgpA/RgpB/Kgp cells or the Lys-gingipain (Kgp) mutant K1A cells do not induce apoptosis in human gingvial epithelial cells | Porphyromonas gingivalis |
physiological function | live Porphyromonas gingivalis can invoke gingival epithelial cell apoptosis in a time and dose dependent manner with significant apoptosis occurring between 12 and 24 hours of challenge via a gingipain-dependent mechanism. Either arginine or lysine gingipains are necessary and sufficient factors in Porphyromonas gingivalis elicited apoptosis | Porphyromonas gingivalis |