Any feedback?
Literature summary for 3.4.22.47 extracted from
- Pancreatic secretory trypsin inhibitor acts as an effective inhibitor of cysteine proteinases gingipains from Porphyromonas gingivalis (2008), J. Periodont. Res., 43, 232-236.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | activation of gingipain R by incubation for 10 min in 200 mM Tris-HCl buffer, pH 7.6, containing 50 mM Gly-Gly, 10 mM CaCl2 and 10 mM Cys-HCl | Porphyromonas gingivalis |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | development of potent, gingipain-specific inhibitors might be a helpful tool in a therapeutic strategy to prevent or treat periodontal disease | Porphyromonas gingivalis |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| benzamidine derivatives | - |
Porphyromonas gingivalis |  |
| carbobenzoxy-Glu(NHN(CH3)Ph)-Lys-CO-NHCH2Ph | - |
Porphyromonas gingivalis | |
| carbobenzoxy-Lys-Arg-CO-Lys-N-(CH3)2 | - |
Porphyromonas gingivalis | |
| Chloromethylketones | - |
Porphyromonas gingivalis | |
| EDTA | - |
Porphyromonas gingivalis | |
| iodoacetamide | - |
Porphyromonas gingivalis | |
| leupeptin | - |
Porphyromonas gingivalis | |
| additional information | no inhibition by chicken ovoinhibitor III and IV domains | Porphyromonas gingivalis | |
| porcine pancreatic secretory trypsin inhibitor | i.e. PSTI porcine, a Kazal-type serine proteinase inhibitor purified from pancreas, porcine pancreatic secretory trypsin inhibitor having an essential Lys residue at the P1 position of the reactive site, and containing Tyr and Asn residues the P2' and P3' sites, specifically inhibits the activity of the Lys-specific gingipain K, whereas bovine inhibitor, possessing a Arg residue at the P1 position, exhibits activity only against the Arg-specific cysteine proteinase gingipain K, EC 3.4.22.37. The association equilibrium constant is 0.51 mM | Porphyromonas gingivalis | |
| tetracycline | - |
Porphyromonas gingivalis | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Porphyromonas gingivalis | gingipains are key virulence determinants of Porphyromonas gingivalis and play a crucial role in pathogenicity | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Porphyromonas gingivalis | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | gingipains are key virulence determinants of Porphyromonas gingivalis and play a crucial role in pathogenicity | Porphyromonas gingivalis | ? | - |
? | |
| N-alpha-benzoyl-DL-lysine 4-nitroanilide + H2O | - |
Porphyromonas gingivalis | N-alpha-benzoyl-DL-lysine + 4-nitroaniline | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| gingipain K | - |
Porphyromonas gingivalis |
| KGP | - |
Porphyromonas gingivalis |
| Lys-specific cysteine proteinase gingipain | - |
Porphyromonas gingivalis |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 22 | - |
assay at | Porphyromonas gingivalis |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.6 | 8.3 | assay at | Porphyromonas gingivalis |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
