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Literature summary for 3.4.22.47 extracted from

  • Liu, X.; Sroka, A.; Potempa, J.; Genco, C.A.
    Coordinate expression of the Porphyromonas gingivalis lysine-specific gingipain proteinase, Kgp, arginine-specific gingipain proteinase, RgpA, and the heme/hemoglobin receptor, HmuR (2004), Biol. Chem., 385, 1049-1057.
    View publication on PubMed
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Protein Variants

Protein Variants Comment Organism
additional information kgp-deficient mutant strain WS10 shows 22 fold increased hmuR expression, while the kgp expression is decreased in the hmuR-deficient mutant strain WS1 Porphyromonas gingivalis

Inhibitors

Inhibitors Comment Organism Structure
Z-Phe-Lys-2,4,6-trimethyl-benzoyloxymethyl-ketone specific inhibition of Kgp Porphyromonas gingivalis

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane associated Porphyromonas gingivalis 16020
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Porphyromonas gingivalis the enzyme degrades host iron- and heme-containing proteins, regulation of enzyme expression, overview, inhibition of gingipain increases the hmuR gene expression encoding the heme/hemoglobin receptor HmuR, and decreases the cell growth in the early and middle stages, but not in the late stages, hmuR expression inhibition decreases enzyme expression ?
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 ?

Organism

Organism UniProt Comment Textmining
Porphyromonas gingivalis
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 gene kgp
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme degrades host iron- and heme-containing proteins, regulation of enzyme expression, overview, inhibition of gingipain increases the hmuR gene expression encoding the heme/hemoglobin receptor HmuR, and decreases the cell growth in the early and middle stages, but not in the late stages, hmuR expression inhibition decreases enzyme expression Porphyromonas gingivalis ?
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 ?

Synonyms

Synonyms Comment Organism
KGP
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 Porphyromonas gingivalis
lysine-specific gingipain proteinase
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 Porphyromonas gingivalis