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Literature summary for 3.4.22.46 extracted from
- The leader proteinase of foot-and-mouth disease virus: structure-function relationships in a proteolytic virulence factor (2014), Biol. Chem., 395, 1179-1185.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| eukaryotic initiation factor eIF4G + H2O | Foot-and-mouth disease virus | - |
? | - |
? |  |
| nuclear factor-kappaB + H2O | Foot-and-mouth disease virus | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Foot-and-mouth disease virus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| eukaryotic initiation factor eIF4G + H2O | - |
Foot-and-mouth disease virus | ? | - |
? | |
| nuclear factor-kappaB + H2O | - |
Foot-and-mouth disease virus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Leader proteinase | - |
Foot-and-mouth disease virus |
| Lpro | - |
Foot-and-mouth disease virus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the enzyme inhibits the host innate immune response by the revention of the synthesis of cytokines such as interferons immediately after infection (brought about by specific proteolytic cleavage of the eukaryotic initiation factor 4G) as well as nuclear factor-kappaB cleavage and the deubiquitination of immune signalling molecules | Foot-and-mouth disease virus |
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Release 2023.1 (January 2023)
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