Literature summary for 3.4.22.46 extracted from

de Los Santos, T.; Diaz-San Segundo, F.; Grubman, M.J.
Degradation of nuclear factor kappa B during foot-and-mouth disease virus infection (2007), J. Virol., 81, 12803-12815.

Search for more literature for 3.4.22.46

Protein Variants

Protein Variants	Comment	Organism
additional information	Lpro regulates the activity of nuclear factor kappa B. Analysis of NF-kappa B-dependent reporter gene expression in BHK-21 cells (baby hamster kidney cells strain 21), demonstrate that infection with wild-type virus has an inhibitory effect compared to infection with a genetically engineered mutant (A12-LLV2) lacking the leader coding region	Foot-and-mouth disease virus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
nucleus	Lpro is localized to the nucleus of infected cells, and there is a correlation between the translocation of Lpro and the decrease in the amount of nuclear p65/RelA, a subunit of NF-kappa B	Foot-and-mouth disease virus	5634	-

Organism

Organism	UniProt	Comment	Textmining
Foot-and-mouth disease virus	-	-	-

Synonyms

Synonyms	Comment	Organism
Lbpro	-	Foot-and-mouth disease virus
Leader proteinase	-	Foot-and-mouth disease virus

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Release 2023.1 (January 2023)