Protein Variants | Comment | Organism |
---|---|---|
additional information | a mutant virus A12-LLV2 lacking the leader proteinase is attenuated in cell culture and susceptible animals due to the inability of the mutant virus to block the expression of type I interferon alpha/beta, the blockade results in the IFN-induced inhibition of FMDV replication, overview | Foot-and-mouth disease virus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
eukaryotic translation initiation factor eIF4GI + H2O | Foot-and-mouth disease virus | eukaryotic host cell protein substrate, cleavage causes the rapid inhibition of cellular cap-dependent protein synthesis | ? | - |
? | |
eukaryotic translation initiation factor eIF4GI + H2O | Foot-and-mouth disease virus FMDV | eukaryotic host cell protein substrate, cleavage causes the rapid inhibition of cellular cap-dependent protein synthesis | ? | - |
? | |
additional information | Foot-and-mouth disease virus | the enzyme inhibits the immediate-early induction of beta interferon mRNA and blocks the host innate immune response by inhibition of IFN-induction of double-stranded RNA-dependent protein kinase R, 2',5'-oligoadenylate synthase, and Mx1 mRNAs in host porcine cells | ? | - |
? | |
additional information | Foot-and-mouth disease virus FMDV | the enzyme inhibits the immediate-early induction of beta interferon mRNA and blocks the host innate immune response by inhibition of IFN-induction of double-stranded RNA-dependent protein kinase R, 2',5'-oligoadenylate synthase, and Mx1 mRNAs in host porcine cells | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Foot-and-mouth disease virus | - |
FMDV | - |
Foot-and-mouth disease virus FMDV | - |
FMDV | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
eukaryotic translation initiation factor eIF4GI + H2O | eukaryotic host cell protein substrate, cleavage causes the rapid inhibition of cellular cap-dependent protein synthesis | Foot-and-mouth disease virus | ? | - |
? | |
eukaryotic translation initiation factor eIF4GI + H2O | eukaryotic host cell protein substrate | Foot-and-mouth disease virus | ? | - |
? | |
eukaryotic translation initiation factor eIF4GI + H2O | eukaryotic host cell protein substrate, cleavage causes the rapid inhibition of cellular cap-dependent protein synthesis | Foot-and-mouth disease virus FMDV | ? | - |
? | |
eukaryotic translation initiation factor eIF4GI + H2O | eukaryotic host cell protein substrate | Foot-and-mouth disease virus FMDV | ? | - |
? | |
additional information | the enzyme inhibits the immediate-early induction of beta interferon mRNA and blocks the host innate immune response by inhibition of IFN-induction of double-stranded RNA-dependent protein kinase R, 2',5'-oligoadenylate synthase, and Mx1 mRNAs in host porcine cells | Foot-and-mouth disease virus | ? | - |
? | |
additional information | the enzyme inhibits the immediate-early induction of beta interferon mRNA and blocks the host innate immune response by inhibition of IFN-induction of double-stranded RNA-dependent protein kinase R, 2',5'-oligoadenylate synthase, and Mx1 mRNAs in host porcine cells | Foot-and-mouth disease virus FMDV | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Leader proteinase | - |
Foot-and-mouth disease virus |
Lpro | - |
Foot-and-mouth disease virus |