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Literature summary for 3.4.22.46 extracted from

  • Strong, R.; Belsham, G.J.
    Sequential modification of translation initiation factor eIF4GI by two different foot-and-mouth disease virus proteases within infected baby hamster kidney cells: Identification of the 3Cpro cleavage site (2004), J. Gen. Virol., 85, 3817.
No PubMed abstract available

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
eukaryotic translation initiation factor eIF4GI + H2O Foot-and-mouth disease virus eukaryotic host cell protein substrate, cleavage causes the rapid inhibition of cellular cap-dependent protien synthesis ?
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Organism

Organism UniProt Comment Textmining
Foot-and-mouth disease virus
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FMDV O1Kaufbeuren B64, from BHK or A293 cells, two enzymes: leader protease and 3C protease
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
eukaryotic translation initiation factor eIF4GI + H2O eukaryotic host cell protein substrate, cleavage causes the rapid inhibition of cellular cap-dependent protien synthesis Foot-and-mouth disease virus ?
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?
eukaryotic translation initiation factor eIF4GI + H2O eukaryotic host cell protein substrate, activity of 3Cpro and Lpro with wild-type and mutant substrate, overview, the highly specific 3Cpro cleavage site is located at the small 40-amino-acid region of the protein Foot-and-mouth disease virus ?
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additional information elIF4GI cleavage site mapping Foot-and-mouth disease virus ?
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?

Synonyms

Synonyms Comment Organism
3C protease
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Foot-and-mouth disease virus
3Cpro
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Foot-and-mouth disease virus
leader protease
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Foot-and-mouth disease virus
Lpro
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Foot-and-mouth disease virus