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Literature summary for 3.4.22.46 extracted from

  • Kirchweger, R.; Ziegler, E.; Lamphear, B.J.; Waters, D.; Liebig, H.D.; Sommergruber, W.; Sobrino, F.; Hohenadl, C.; Blaas, D.; Rhoads, R.E.; Skern, T.
    Foot-and-mouth disease virus leader proteinase: purification of the Lb form and determination of its cleavage site on eIF-4gamma (1994), J. Virol., 68, 5677-5684.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
-
Foot-and-mouth disease virus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
20000
-
gel filtration Foot-and-mouth disease virus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
foot-and-mouth disease leader protein + H2O Foot-and-mouth disease virus similar to other papain-like proteinases the enzyme possesses the catalytic cysteine and histidine residues, however the catalytic asparagine has been replaced by an aspartate. The interaction between the histidine and aspartate is exposed to solvent, as the tryptophan residues are missing. The cleavage site is between its own C-terminus and the N-terminus of VP4 ?
-
?
translation initiation factor eIF4G + H2O Foot-and-mouth disease virus
-
additional information characterization of cleavage products, primary cleavage of rabbit reticulocyte eIF-4-gamma occurs between Gly479-Arg480, complete proteolysis after 12 h ?

Organism

Organism UniProt Comment Textmining
Foot-and-mouth disease virus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Foot-and-mouth disease virus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
foot-and-mouth disease leader protein + H2O similar to other papain-like proteinases the enzyme possesses the catalytic cysteine and histidine residues, however the catalytic asparagine has been replaced by an aspartate. The interaction between the histidine and aspartate is exposed to solvent, as the tryptophan residues are missing. The cleavage site is between its own C-terminus and the N-terminus of VP4 Foot-and-mouth disease virus ?
-
?
translation initiation factor eIF4G + H2O
-
Foot-and-mouth disease virus additional information characterization of cleavage products, primary cleavage of rabbit reticulocyte eIF-4-gamma occurs between Gly479-Arg480, complete proteolysis after 12 h ?