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Literature summary for 3.4.22.40 extracted from

  • Kamata, Y.; Yamamoto, M.; Kawakami, F.; Tsuboi, R.; Takeda, A.; Ishihara, K.; Hibino, T.
    Bleomycin hydrolase is regulated biphasically in a differentiation- and cytokine-dependent manner: relevance to atopic dermatitis (2011), J. Biol. Chem., 286, 8204-8212.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
corneocyte
-
Homo sapiens
-
keratinocyte
-
Homo sapiens
-
skin
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
citrulline-7-amido-4-methylcoumarin + H2O
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Homo sapiens citrulline + 7-amino-4-methylcoumarin
-
?

Expression

Organism Comment Expression
Homo sapiens interferon-gamma significantly reduces the expression of bleomycin hydrolase. The enzyme activity and expression are markedly decreased in atopic dermatitis lesional and non-lesional skin (to 27.1 and 8.8%, respectively) down
Homo sapiens interleukin-4 does not show any direct effect on bleomycin hydrolase expression additional information
Homo sapiens bleomycin hydrolase expression is up-regulated via IRF-1/2, MZF-1 and Sp-1. mRNA is up-regulated in keratinocytes when cultured at high calcium concentration (6.8fold) up