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Literature summary for 3.4.22.39 extracted from

  • McGrath, W.J.; Baniecki, M.L.; Li, C.; McWhirter, S.M.; Brown, M.T.; Toledo, D.L.; Mangel, W.F.
    Human adenovirus proteinase: DNA binding and stimulation of proteinase activity by DNA (2001), Biochemistry, 40, 13237-13245.
    View publication on PubMed
Search for more literature for 3.4.22.39

Activating Compound

Activating Compound Comment Organism Structure
pVIc the enzyme requires two cofactors for maximal activity,the 11-amino acid residue peptide from the C-terminus of adenovirus precursor protein and the viral DNA Human adenovirus sp.
viral DNA the enzyme requires two cofactors for maximal activity, the 11-amino acid residue peptide from the C-terminus of adenovirus precursor protein and the viral DNA Human adenovirus sp.

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0034
-
 (Leu-Arg-Gly-Gly-NH)2-rhodamine pH 8.0, 25°C, activation by viral DNA and the 11-amino acid residue peptide from the C-terminus of adenovirus precursor protein and the viral DNA Human adenovirus sp.
0.0092
-
 (Leu-Arg-Gly-Gly-NH)2-rhodamine pH 8.0, 25°C, activation by viral DNA Human adenovirus sp.
0.0099
-
 (Leu-Arg-Gly-Gly-NH)2-rhodamine pH 8.0, 25°C, activation by the the 11-amino acid residue peptide from the C-terminus of adenovirus precursor protein and the viral DNA Human adenovirus sp.
0.0948
-
 (Leu-Arg-Gly-Gly-NH)2-rhodamine pH 8.0, 25°C, in absence of any cofactor Human adenovirus sp.

Organism

Organism UniProt Comment Textmining
Human adenovirus sp.
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(Leu-Arg-Gly-Gly-NH)2-rhodamine + H2O
-
 Human adenovirus sp. ?
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.0023
-
 (Leu-Arg-Gly-Gly-NH)2-rhodamine pH 8.0, 25°C, in absence of any cofactor Human adenovirus sp.
0.0248
-
 (Leu-Arg-Gly-Gly-NH)2-rhodamine pH 8.0, 25°C, activation by viral DNA Human adenovirus sp.
0.271
-
 (Leu-Arg-Gly-Gly-NH)2-rhodamine pH 8.0, 25°C, activation by the the 11-amino acid residue peptide from the C-terminus of adenovirus precursor protein and the viral DNA Human adenovirus sp.
2.78
-
 (Leu-Arg-Gly-Gly-NH)2-rhodamine pH 8.0, 25°C, activation by viral DNA and the 11-amino acid residue peptide from the C-terminus of adenovirus precursor protein and the viral DNA Human adenovirus sp.
3 6 (Leu-Arg-Gly-Gly-NH)2-rhodamine pH 8.0, 25°C, activation by viral DNA and the 11-amino acid residue peptide from the C-terminus of adenovirus precursor protein and the viral DNA Human adenovirus sp.