Literature summary for 3.4.22.38 extracted from

Hira, V.V.; Verbovsek, U.; Breznik, B.; Srdic, M.; Novinec, M.; Kakar, H.; Wormer, J.; der Swaan, B.V.; Lenarcic, B.; Juliano, L.; Mehta, S.; Van Noorden, C.J.; Lah, T.T.
Cathepsin K cleavage of SDF-1alpha inhibits its chemotactic activity towards glioblastoma stem-like cells (2017), Biochim. Biophys. Acta Mol. Cell Res., 1864, 594-603 .

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Application

Application	Comment	Organism
medicine	activation of cathepsin K may be a promising strategy to prevent homing of therapy-resistant glioma stem-like cells (GSLCs) in niches and thus render these cells sensitive to chemotherapy and radiation	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
chemo-attractant stromal-derived factor-1alpha + H2O	Homo sapiens	the enzyme cleaves chemo-attractant stromal-derived factor-1alpha (SDF-1alpha) at 3 sites in the N-terminus, which is the region of SDF-1alpha that binds to its receptors	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P43235	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
glioblastoma cell	cathepsin K, the chemo-attractant stromal-derived factor-1alpha and its C-X-C receptor type 4 are localized in therapy-resistant glioma stem-like cell (GSLC) niches in glioblastoma	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
chemo-attractant stromal-derived factor-1alpha + H2O	the enzyme cleaves chemo-attractant stromal-derived factor-1alpha (SDF-1alpha) at 3 sites in the N-terminus, which is the region of SDF-1alpha that binds to its receptors	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
catK	-	Homo sapiens

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Release 2023.1 (January 2023)