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Literature summary for 3.4.22.38 extracted from

  • Schmit, J.M.; Pondenis, H.C.; Barger, A.M.; Borst, L.B.; Garrett, L.D.; Wypij, J.M.; Neumann, Z.L.; Fan, T.M.
    Cathepsin K expression and activity in canine osteosarcoma (2012), J. Vet. Intern. Med., 26, 126-134.
    View publication on PubMed
Search for more literature for 3.4.22.38

Application

Application Comment Organism
medicine cathepsin K inhibitors may aid in the management of canine osteosarcoma-related malignant osteolysis Canis lupus familiaris

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasmic vesicle
-
 Canis lupus familiaris 31410
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
37000
-
 x * 37000, inactive propeptide, SDS-PAGE Canis lupus familiaris

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Collagen type I + H2O Canis lupus familiaris
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Canis lupus familiaris
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Abrams cell
-
 Canis lupus familiaris
-
COS-31 cell
-
 Canis lupus familiaris
-
D17 cell
-
 Canis lupus familiaris
-
HMPOS cell
-
 Canis lupus familiaris
-
osteoclast
-
 Canis lupus familiaris
-
osteosarcoma cell
-
 Canis lupus familiaris
-
POS cell
-
 Canis lupus familiaris
-
serum
-
 Canis lupus familiaris
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Collagen type I + H2O
-
 Canis lupus familiaris ?
-
 ?

Subunits

Subunits Comment Organism
? x * 37000, inactive propeptide, SDS-PAGE Canis lupus familiaris

Synonyms

Synonyms Comment Organism
catK
-
 Canis lupus familiaris

Expression

Organism Comment Expression
Canis lupus familiaris in osteosarcoma cells, tissue growth factor beta1 induces the secretion of cathepsin K by about 3fold up