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Literature summary for 3.4.22.38 extracted from

  • Lewiecki, E.M.
    Odanacatib, a cathepsin K inhibitor for the treatment of osteoporosis and other skeletal disorders associated with excessive bone remodeling (2009), IDrugs, 12, 799-809.
    View publication on PubMed

Application

Application Comment Organism
medicine because excessive bone remodeling is a key element in the pathogenesis of postmenopausal osteoporosis and other skeletal disorders, cathepsin K is a potential target for therapeutic intervention Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
odanacatib MK-0822 or MK-822 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
Homo sapiens 5764
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
collagen I + H2O Homo sapiens
-
?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
osteoclast
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
collagen I + H2O
-
Homo sapiens ?
-
?

General Information

General Information Comment Organism
physiological function cathepsin K acts as the major collagenase responsible for the degradation of the organic bone matrix during the bone remodeling process Homo sapiens