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Literature summary for 3.4.22.38 extracted from

  • Barascuk, N.; Skjot-Arkil, H.; Register, T.C.; Larsen, L.; Byrjalsen, I.; Christiansen, C.; Karsdal, M.A.
    Human macrophage foam cells degrade atherosclerotic plaques through cathepsin K mediated processes (2010), BMC Cardiovasc. Disord., 10, 19.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
type I collagen + H2O Homo sapiens
-
 C-terminal telopeptide of type I collagen + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
coronary artery left anterior descending coronary arteries with different degrees of atherosclerotic lesions, cathepsin K co-localizes with collagen type I in advanced atherosclerotic lesions especially at the plaque shoulders Homo sapiens
-
macrophage foam cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
type I collagen + H2O
-
 Homo sapiens C-terminal telopeptide of type I collagen + ?
-
 ?

Synonyms

Synonyms Comment Organism
cathepsin-K
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function human macrophage foam cells degrade atherosclerotic plaques though cathepsin K-mediated processes, resulting in increase in levels of C-terminal fragments of type I collagen Homo sapiens