Literature summary for 3.4.22.38 extracted from

Srivastava, M.; Steinwede, K.; Kiviranta, R.; Morko, J.; Hoymann, H.G.; Laenger, F.; Buhling, F.; Welte, T.; Maus, U.A.
Overexpression of cathepsin K in mice decreases collagen deposition and lung resistance in response to bleomycin-induced pulmonary fibrosis (2008), Respir. Res., 9, 54.

Search for more literature for 3.4.22.38

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	the enzyme is induced by bleomycin in the lung	Mus musculus

Application

Application	Comment	Organism
drug development	lysosomal cysteine protease is an interesting target molecule with therapeutic potential to attenuate bleomycin-induced pulmonary fibrosis in mice	Mus musculus

Cloned(Commentary)

Cloned (Comment)	Organism
quantitative expression analysis by RT-PCR	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
additional information	overexpression of cathepsin K in mice decreases collagen deposition and lung resistance in response to bleomycin-induced pulmonary fibrosis, overview. Cathepsin K protein levels are strongly increased in alveolar macrophages and lung parenchymal tissue of mock-treated cathepsin K transgenic mice relative to wild-type mice	Mus musculus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
lysosome	-	Mus musculus	5764	-

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	FVB/N mice	-
Mus musculus FVB/N	-	FVB/N mice	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
epithelial cell	primary type II alveolar epithelial cells	Mus musculus	-
fibroblast	-	Mus musculus	-
lung	qunatitative determination of enzyme content by immunohistochemistry, real time RT-PCR and western blotting	Mus musculus	-
macrophage	alveolar	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
cath K	-	Mus musculus

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Release 2023.1 (January 2023)